PURPOSE: A composition containing crude drug extract is provided to be used as a therapeutic agent for treating gastrointestinal disorders. CONSTITUTION: A method for preparing Corydalis Tuber Pharbitis seed extract or a mixture thereof with reduced toxicity comprises a step of mixing Corydalis Tuber Pharbitis seed or a mixture thereof using water low alcohol of C1-4 or a mixture solvent thereof at 10-15 Deg. C. for24-72 hours. The solvent is 30-70% ethanol solution. A pharmaceutical composition...

PROBLEM TO BE SOLVED: To provide compounds that are more susceptible to degradation by serum and/or cytosolic esterases than cisapride, thus avoiding the adverse effects associated with metabolism by cytochrome P450.

The subject invention provides novel compounds and compositions for the safe and effective treatment of gastroesophageal reflux and related conditions. In a preferred embodiment, the compositions of the subject invention comprise esterified cisapride derivatives. These compositions possess potent activity in treating gastroesophageal reflux disease and substantially reduce adverse effects associated with the administration of cisapride. These adverse effects include, but are not limited to, diar...

In accordance with this invention there is provided a granular product with an effervescent system which comprises acid-sensitive pharmaceutically active substances such as for example beta-carotene cimetidine ranitidine or cisapride which is specially useful to prevent antacid action having an acid-binding capacity below about 5meq at a weight of about 1.6 to about 2.3 grams. The effervescent grains are made from carrier crystals of at least one solid edible organic acid preferably citric acid ...

This invention concerns a new process of preparing cisapride and the pharmaceutically acceptable acid addition salts thereof by reductively aminating 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4- piperidinone in the presence of benzylamine under hydrogen in a reaction-inert solvent yielding 1-[3-(4-fluorophenoxy)-propyl]-3-metho xy- 4-piperidinamine having a cis/trans ratio of about 93/7 which is enriched in the amount of cis-stereoisomer by converting it into its acid addition salt by treatment w...

A composition comprising (+) cisapride or a pharmaceutically acceptable salt thereof wherein: The composition is for eliciting an antiemetic effect in a human by administering an amount thereof sufficient to alleviate nausea and vomiting whilst being insufficient to cause adverse side-effects associated with the administration of racemic cisapride or while achieving a higher bioavailability than achieved with racemic cisapride; or the composition is for treating a condition caused by gastrointes...