The present invention provides a pharmaceutical formulation comprising voriconazole or a pharmaceutically acceptable derivative thereof and an excipient of formula (I) i.e. monomethoxy poly(ethylene glycol)-poly (DL-lactic acid) block copolymers (mPEG-PDLLA). The pharmaceutical formulation of the present invention has been shown to be stable and safe by experiments.

The present invention relates to a pharmaceutical composition comprising voriconazole and an aqueous, non-aqueous, or oily vehicle, or a mixture thereof, and optionally one or more pharmaceutically acceptable excipients

Provided is a process for preparing Voriconazole represented by Chemical Formula 1. More particularly the process for preparing Voriconazole of Chemical Formula 1 includes: carrying out the Reformatsky-type coupling reaction between a ketone derivative of Chemical Formula 4 and a pyrimidine derivative of Chemical Formula 5 to obtain a compound of Chemical Formula 3; reacting the substituents halo and oxysulfonyl with a hydrogen donor to obtain racemic Voriconazole of Chemical Formula 2; and carr...

Voriconazole is prepared by a process comprising condensing 1-(24-difluorophenyl)-2-(1H-124-triazole-1-yl)ethanone with 4-chloro-6-ethyl-5-fluoropyrimidine in a ketone ether aliphatic hydrocarbon or aromatic hydrocarbon solvent to give (2R 3S/2S3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(24-diflurophenyl)-1-(1H-124-triazole-1-yl)butan-2-ol.

The present invention relates to an improved stereoselective process for the preparation of (2R,3S/2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-difluorophenyl)- 1-(1H-l,2,4-triazol-1-yl)butan-2-ol intermediate compound. This intermediate compound is further used to prepare voriconazole - a triazole antifungal agent.

Methods and formulations for preparing spray dried pharmaceutical products including daptomycin azithromycin cyclophosphamide and voriconazole.