Tranylcypromine derivatives useful as therapeutic agents particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2 such as the diseases characterized by deregulation of gene transcription cell differentiation and proliferation e.g. tumors viral infections are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to ...

Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relat...

Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R are as defined in the specification. The invention also relate...

Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relat...

Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relat...

1. A pharmaceutical composition for the treatment of acute chronic and/or neuropathic pain and migraine comprising (a) a nicotine receptor partial agonist or a pharmaceutical acceptable salt thereof; (b) an analgesic agent or pharmaceutically acceptable salt thereof and (c) a pharmaceutical acceptable carrier; wherein the active agents "a" and "b" above are present in amounts that render the composition effective in treating acute chronic and/or neuropathic pain and migraine. 2. The pharmaceutic...

PURPOSE: Pharmaceutical compositions are provided for the treatment of nicotine dependence or addiction tobacco dependence or addiction reduction of nicotine withdrawal symptoms or aiding in the cessation or lessening of tobacco use or substance abuse. CONSTITUTION: The therapeutically effective pharmaceutical combination is comprised of a nicotine receptor partial agonist and an anti-depressant or anxiolytic agent and a pharmaceutically acceptable carrier. In a more specific embodiment the anti...