L'INVENTION CONCERNE UNE PREPARATION PHARMACEUTIQUE A ACTION ANTI-HYPERTENSIVE ET CARDIOPROTECTRICE QUI CONTIENT EN DEHORS DES EXCIPIENTS OU ADJUVANTS USUELS DE L'A- ISOPROPYL-A- (N-METHYL-N-HOMOVERATRYL)-G -AMINOPROPYL-34-DIMETHOXYPHENYL-ACETONITRILE SOUS FORME D'UN SEL D'ADDITION D'ACIDE ACCEPTABLE PHARMACOLOGIQUEMENT DE LA 247-TRIAMINO-6-PHENYLPTERIDINE (TRIAMTERENE) ET DU 6-CHLORO-34-DIHYDRO-7-SULFAMOYL-2H-124-BENZOTHIADIAZINE-11-DIOXYDE (HYDROCHLOROTHIAZIDE) EN TANT QUE SUBTANCES ACTIVES SO...

A diuretically active pharmacological composition which comprises 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid (furosemide) together with at least one compound of formula (I) (I) wherein R is a hydrophilic radical capable of increasing the water solubility of the resulting compound together with a suitable pharmacological carrier.(From US4335119 A)

Pteridine derivs. (I) and salts are new. A = spacer gp.; and R = 1-4C alkyl or opt. substd. aryl. A is pref. arylene or alkylarylene with 6-18C or a 5- or 6- membered heterocyclic gp. contg. at least 2 C and N O or S atom(s) esp. 14-phenylene or a gp. of the formula (II) or (III). Y = O or -(CHR1)n-; R1 = H 1-4C OH or di-1-4C alkylamino and n = 0-2. USE/ADVANTAGE - Admin. is pref. parenterally at 0.2-1000 mg/day and the molar ratio (I):furosemide is e.g. 0.5:1. Higher water solubility than triam...

In the case of a multiple gear gearbox the loose gear of one of two immediately adjacent permanently engaged gear pairs is supported on the axially extended hub of the loose gear of the other gear pair and carries its shift dogs on the end face remote from the latter loose gear. Its shift dogs are arranged on the free end of the extended hub. In order to permit the transmission of high torques by means of a simple design with few components a small overall axial length and high reliability an ax...

A diuretic pharmaceutically acceptable solution of triamterene and solutions of triamterene and hydrochlorothiazide to provide an antihypertensive and diuretic effect for those in need thereof. Triamterene is solubilized in a combination of a glycol and lactic acid present in an amount sufficient to maintain the triamterene in solution. A pharmaceutically acceptable diluent such as glycerin is also present.

PURPOSE: To obtain the title clathrate body capable of utilizing an insoluble drug as a rapidly soluble drug and being simple in production process by subjecting drug powder selected from a group of reserpine nalidixic acid and medazepam to roll blending with cyclodextrins powder under anhydrous conditions and including the drug powder into cyclodextrin powder.CONSTITUTION: One or two or more kind of powder of drugs selected from a group consisting of reserpine nalidixic acid medazepam phenytoin...

PURPOSE: To obtain the subject medicine solution useful as a diuretic medicine solution high in antihypertensive characteristics by blending triamterene as a diuretic and optionally hydrochlorothiazide with specific amounts of glycol and a lactic acid so as to solubilize triamterene. CONSTITUTION: Triamterene (247-triamino-6-phenylpteridine) which is a diuretic existing in a medically effective amount of 5-10mg/ml is blended with optionally hydrochlorothiazide (its combination provides a diureti...