The present invention relates to compositions comprising thioridazine and derivatives thereof together with antibacterials. These compositions have been found greatly enhance the activity of many classes of antibacterials allowing the antibacterials to be administered at significantly lower doses. The thioridazine and the antibacterial act synergistically by pacifying the bacteria to the antibacterials. This synergistic affect lowering the inhibitory or effective concentration of the antimicrobi...

Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and/or subjects likely to be responsive to therapy with DR receptor antago...

Described are methods, uses, combinations and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods, uses, combinations and compositions are useful for the treatment of cancers such as acute myeloid leukemia.

Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and methods for identifying subjects likely to be responsive to therapy wi...

ABSTRACT - 592437 Disclosed herein is a dosage form comprising: at least one form of tapentadol at least one opioid antagonist and a second analgesic wherein the said opioid antagonist improves the efficacy and or reduces the side effects of tapentadol and wherein said opioid antagonist is selected from the group consisting of naloxone naltrexone nalmefene methylnaltrexone nalide nalmexone nalorphine naluphine haloperidol promethazine fluphenazine perphenazine levomepromazine thioridazine perazi...

Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and methods for identifying subjects likely to be responsive to therapy wi...

Disclosed is the use of a dopamine receptor D2 inhibitor medicament for treating depression improving cognition and/or treating other syndromes conditions or diseases for which anti-depressant agents are prescribed. The dopamine receptor D2 inhibitor medicament is formulated for administration in an administration cycle the administration cycle comprising: i. administering the D2 receptor inhibitor to elevate amounts of the D2 receptor's high affinity state inducing dopamine receptor supersensit...

Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and methods for identifying subjects likely to be responsive to therapy wi...

The present invention relates to compositions comprising thioridazine and derivatives thereof together with antibacterials . These compositions have been found greatly enhance the activity of many classes of antibacterials allowing the antibacterials to be administered at significantly lower doses. The thioridazine and the antibacterial act synergistically by pacifying the bacteria to the antibacterials. This synergistic affect lowering the inhibitory or effective concentration of the antimicrob...

A method for treating coronavirus infection by administering to a subject in need of the treatment an effective amount of one or more of the following compounds: aklavin sanguinarine amiodarone chlorpromazine clomiphene dihydroergotamine dipyridamole emetine ephedrine prochlorperazine promazine propiomazine aminacrine fluphenazine fenoterol peruvoside proglumide atenolol nerifolin nefopam cycloheximide avermectin B1 bepridil cinnarizine ethisterone pararosaniline methylbenzethonium niclosamide p...