A preparation method of micromolecule anticoagulant ticagrelor, an intermediate for synthesizing ticagrelor and a preparation method of the intermediate. With the synthesis method, the side reaction in the reaction process can be effectively reduced, the purity of the intermediate is improved, and the purifying way of the intermediate is simplified.

The present invention is related to new intermediates and processes for preparing Ticagrelor disclosed in this patent application.

The present invention relates to a solid pharmaceutical dosage form comprising ticagrelor as pharmaceutically active ingredient to certain particles of ticagrelor and to processes of preparing the same.

A process for the preparation of 4,6-dihalopyrimidin-5-aminesof formula (II), or salts thereof, which comprises reacting 5-aminopyrimidin-4,6-diols of formula (III), or salts thereof, or a solvate either of the compound of formula (III) or of a salt thereof, with a halogenating agent, new intermediates useful in the preparation of the compound of formula (II) and processes for the preparation of these intermediates. The invention also refers to a process for the preparation of ticagrelor or a ph...