专利信息

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专利标题：Manufacturing process for tiotropium bromide

The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as a long-acting anticholinergic bronchodilator. Starting from oxalic acid derivative of formula III the invention describes preparation of a novel cyclic anhydride of formula II which is very efficient precursor in the synthesis of Tiotropium bromide (compound of formula I).

专利标题：NEW TIOTROPIUM BROMIDE CRYSTALLINE FORM

专利权人：BILGIC MAHMUT [TR];

The present invention is related to crystalline compound comprising Tiotropium bromide and the process that shall be used in production of said compound.

专利标题：TIOTROPIUM SALTS, PHARMACEUTICAL FORMULATIONS CONTAINING THE SALTS AND THE USE THEREOF

专利权人：BOEHRINGER INGELHEIM INT [DE];

专利标题：TIOTROPIUM PREPARATIONS

专利权人：XSPRAY MICROPARTICLES AB [SE];

The present invention relates methods of preparing particles of tiotropium bromide particularly useful for inhalationdelivery, the particles obtained from such methods, and their use in pharmaceutical compositions for treatment of respiratory disorders, such as COPD (chronic obstructive pulmonary disease) and asthma.

专利标题：Tiotropium preparations

专利权人：XSPRAY MICROPARTICLES AB [SE];

The present invention relates methods of preparing particles of tiotropium bromide particularly useful for inhalation delivery, the particles obtained from such methods, and their use in pharmaceutical compositions for treatment of respiratory disorders, such as COPD (chronic obstructive pulmonary disease) and asthma.

专利标题：NOVEL FORMS OF TIOTROPIUM BROMIDE AND PROCESSES FOR PREPARATION THEREOF

专利权人：SCIOR INC [US];

This invention relates to novel crystalline forms of tiotropium bromide, processes for preparing them, and their use in pharmaceutical formulations.

专利标题：Novel forms of tiotropium bromide and processes for preparation thereof

专利权人：Sicor Inc.;

This invention relates to novel crystalline forms of tiotropium bromide processes for preparing them and their use in pharmaceutical formulations.

专利标题：Inhalable particles comprising tiotropium

专利权人：Laboratorios Liconsa, S.a.;

The present invention relates to inhalable particles comprising a stabilized amorphous form of tiotropium with a stabilizing agent. It also relates to inhalable particles comprising a stabilized amorphous form of tiotropium with a stabilizing agent mixed with one or more coarse excipients having a mean particle size of 15 to 250 μm. It also relates to a pharmaceutical composition comprising the inhalable particles of the invention to a process for their preparation and to their use for the pr...

专利标题：Use of tiotropium salts in the treatment of severe persistant asthma

The instant invention relates to the use of tiotropium salts for the manufacture of a medicament for the treatment of patients suffering from severe persistent asthma.

专利标题：CRYSTALLINE TIOTROPIUM IODIDE, THE PHARMACEUTICAL FORMULATION CONTAINING THE SAME AND THE USE THEREOF

专利权人：BOEHRINGER INGELHEIM INT [DE];

当前查询条件: [药品] 包含 'Tiotropium'

	查询范围	在当前结果中查询
!	专利类型	发明实用新型外观设计
!	公开号			CN1234
!	申请号			CN1234
!	专利标题		扩展	PHARMA
!	专利权人		扩展	pfizer
	发明人
!	申请日			yyyymmdd
!	公开日			yyyymmdd
	优先权号
!	摘要		扩展	PHARMA
	IPC			A01B

1. US8680297B2	2014/3/25
专利标题：Manufacturing process for tiotropium bromide 专利权人：Drug Process Licensing Assoc., Llc; The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as a long-acting anticholinergic bronchodilator. Starting from oxalic acid derivative of formula III the invention describes preparation of a novel cyclic anhydride of formula II which is very efficient precursor in the synthesis of Tiotropium bromide (compound of formula I).

2. WO2014042605A1	2014/3/20	WO2013TR00290	2013/9/10
专利标题：NEW TIOTROPIUM BROMIDE CRYSTALLINE FORM 专利权人：BILGIC MAHMUT [TR]; The present invention is related to crystalline compound comprising Tiotropium bromide and the process that shall be used in production of said compound.

3. HK1129111A1	2014/3/14	HK20090108607	2007/5/25
专利标题：TIOTROPIUM SALTS, PHARMACEUTICAL FORMULATIONS CONTAINING THE SALTS AND THE USE THEREOF 专利权人：BOEHRINGER INGELHEIM INT [DE];

4. WO2014039001A1	2014/3/13	WO2013SE51039	2013/9/6
专利标题：TIOTROPIUM PREPARATIONS 专利权人：XSPRAY MICROPARTICLES AB [SE]; The present invention relates methods of preparing particles of tiotropium bromide particularly useful for inhalationdelivery, the particles obtained from such methods, and their use in pharmaceutical compositions for treatment of respiratory disorders, such as COPD (chronic obstructive pulmonary disease) and asthma.

5. EP2705838A1	2014/3/12	EP20120183264	2012/9/6
专利标题：Tiotropium preparations 专利权人：XSPRAY MICROPARTICLES AB [SE]; The present invention relates methods of preparing particles of tiotropium bromide particularly useful for inhalation delivery, the particles obtained from such methods, and their use in pharmaceutical compositions for treatment of respiratory disorders, such as COPD (chronic obstructive pulmonary disease) and asthma.

6. US2014057935A1	2014/2/27	US201314068998	2013/10/31
专利标题：NOVEL FORMS OF TIOTROPIUM BROMIDE AND PROCESSES FOR PREPARATION THEREOF 专利权人：SCIOR INC [US]; This invention relates to novel crystalline forms of tiotropium bromide, processes for preparing them, and their use in pharmaceutical formulations.

7. US20140057935A1	2014/2/27
专利标题：Novel forms of tiotropium bromide and processes for preparation thereof 专利权人：Sicor Inc.; This invention relates to novel crystalline forms of tiotropium bromide processes for preparing them and their use in pharmaceutical formulations.

8. AU2009299801B2	2014/2/27
专利标题：Inhalable particles comprising tiotropium 专利权人：Laboratorios Liconsa, S.a.; The present invention relates to inhalable particles comprising a stabilized amorphous form of tiotropium with a stabilizing agent. It also relates to inhalable particles comprising a stabilized amorphous form of tiotropium with a stabilizing agent mixed with one or more coarse excipients having a mean particle size of 15 to 250 μm. It also relates to a pharmaceutical composition comprising the inhalable particles of the invention to a process for their preparation and to their use for the pr...

9. CA2617717C	2014/2/11
专利标题：Use of tiotropium salts in the treatment of severe persistant asthma 专利权人：Boehringer Ingelheim International Gmbh; The instant invention relates to the use of tiotropium salts for the manufacture of a medicament for the treatment of patients suffering from severe persistent asthma.

10. HK1153409A1	2014/1/17	HK20110107748	2011/7/26
专利标题：CRYSTALLINE TIOTROPIUM IODIDE, THE PHARMACEUTICAL FORMULATION CONTAINING THE SAME AND THE USE THEREOF 专利权人：BOEHRINGER INGELHEIM INT [DE];

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