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General Electric Company(21)
Biovail Laboratories International (barbados) Srl(3)
BIOVAIL LAB INTERNAT BARBADOS S R L [BB](2)
IVAX INTERNAT GMBH [CH](2)
GEN ELECTRIC(2)
UNIV CHINA PHARMA(2)
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专利信息
Translation Company
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[药品] 包含 'Tetrabenazine'
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公开号
公开日
申请号
申请日
1.
EP2220085B1
2014/2/12
专利标题
:Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes
专利权人
:
General Electric Company
;
2.
US2014030249A1
2014/1/30
US201314039053
2013/9/27
专利标题
:Pharmaceutical Compositions
专利权人
:
VALEANT INTERNAT BERMUDA [BM]
;
The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent
3.
TW201345528A
2013/11/16
TW20130111748
2013/4/1
专利标题
:Pharmaceutical compositions for combination therapy
专利权人
:
IVAX INTERNAT GMBH [CH]
;
This invention relates to novel pharmaceutical compositions comprising a therapeutically effective combination of a dopaminergic stabilizer known as Pridopidine, and an inhibitor of the vesicular monoamine transporter type 2 (VMAT) known as Tetrabenazine. The pharmaceutical compositions for use according to the invention are contemplated particularly useful for improving the symptomatic therapeutic effects, and for reducing the adverse effects, of Tetrabenazine in the treatment of movement disor...
4.
WO2013152105A1
2013/10/10
WO2013US35124
2013/4/3
专利标题
:PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY
专利权人
:
IVAX INTERNAT GMBH [CH]
;
TEVA PHARMA [US]
;
WATERS ROSS NICHOLAS [SE]
;
WATERS EVA SUSANNA [SE]
;
This invention relates to novel pharmaceutical compositions comprising a therapeutica11y effective combination of a dopaminergic stabilizer known as Pridopidine, and an inhibitor of the vesicular monoamine transporter type 2 (VMAT) known as Tetrabenazine. The pharmaceutical compositions for use according- to the invention are contemplated particularly useful for improving the symptomatic therapeutic effects, and for reducing the adverse effects, of Tetrabenazine in the treatment of movement diso...
5.
US2013267552A1
2013/10/10
US201313856254
2013/4/3
专利标题
:PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY
专利权人
:
WATERS ROSS NICHOLAS [CH]
;
HOLM WATERS EVA SUSANNA [CH]
;
IVAX INTERNAT GMBH [CH]
;
This invention relates to novel pharmaceutical compositions comprising a therapeutically effective combination of a dopaminergic stabilizer known as Pridopidine, and an inhibitor of the vesicular monoamine transporter type 2 (VMAT) known as Tetrabenazine. The pharmaceutical compositions for use according to the invention are contemplated particularly useful for improving the symptomatic therapeutic effects, and for reducing the adverse effects, of Tetrabenazine in the treatment of movement disor...
6.
KR20130088492A
2013/8/8
KR20120009756
2012/1/31
专利标题
:PREPARATION OF TETRABENAZINE AND DIHYDROTETRABENAZINE
专利权人
:
KOREA INST SCI & TECH [KR]
;
PURPOSE: A method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) is provided to simplify a process and to produce a large amount of TBZ or DTBZ. CONSTITUTION: A method for preparing TBZ comprises the steps of: performing alkylation of a compound of chemical formula 3 and a compound of chemical formula 4 to prepare a compound of chemical formula 5
7.
US2013197227A1
2013/8/1
US201213617357
2012/9/14
专利标题
:METHOD OF PREPARING TETRABENAZINE AND DIHYDROTETRABENAZINE
专利权人
:
MIN SUN JOON [KR]
;
CHO YONG SEO [KR]
;
LEE JAE KYUN [KR]
;
PAE AE NIM [KR]
;
SON YOUNG WOOK [KR]
;
KOREA INST SCI & TECH [KR]
;
The present invention relates to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ), and more specifically to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) by using simple and short reaction processes of using 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentane as starting materials to sequentially perform an alkylation reaction, an Aza-Prins cyclization reaction in the presence of an oxidant ...
8.
US20130197227A1
2013/8/1
专利标题
:Method of preparing tetrabenazine and dihydrotetrabenazine
专利权人
:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
;
The present invention relates to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) and more specifically to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) by using simple and short reaction processes of using 67-dimethoxy-1234-tetrahydroisoquinoline and 4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentane as starting materials to sequentially perform an alkylation reaction an Aza-Prins cyclization reaction in the presence of an oxidant and an...
9.
CN101878213B
2013/5/29
专利标题
:Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazinein preparation and probe
专利权人
:
GEN ELECTRIC
;
10.
EP2594568A1
2013/5/22
EP20130155403
2008/11/25
专利标题
:Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
专利权人
:
GEN ELECTRIC [US]
;
The present invention provides novel alpha-fluoroalkyl compounds having structure I and the corresponding dihydrotetrabenazine compounds IV and intermediates useful in the preparation of such compounds. The alpha-fluoroalkyl compounds are provided in both racemic and enantiomerically enriched forms and may comprise either or both of fluorine-18 and fluorine 19. The alpha-fluoroalkyl compounds are shown to possess high affinity for VMAT-2, a biomarker implicated, for example, in human diabetes. T...
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