Disclosed are 2-imino-36-dimethyl-56-diphenyl-tetrahydropyrimidin-4-one derivatives as represented by the general formula (I) wherein R2 is hydrogen; R1 is methyl; W is C(=O); one of R3 or R4 is hydrogen and the other is an optionally substituted phenyl group; U is C(R6)(R7) where one of R6 or R7 is methyl and the other is an optionally substituted phenyl group; and X is NH. Representative compounds include 2-imino-36-dimethyl-5-(4-trifluoromethylphenyl)-6-(24-difluorophenyl)-tetrahydropyrimidin...

Una composición farmacéutica para su uso en el tratamiento o la prevención de la disfunción de neuronas de acetilcolina cerebrales en las secuelas de demencia cerebrovascular demencia senil enfermedad de Alzheimer lesión cerebral isquémica y apoplejía cerebral o la deficiencia de memoria provocada por la muerte neuronal selectiva que comprende los siguientes ingredientes (A) y (B): Ingrediente (A) un derivado de éter de alquilo representado por medio de la fórmula siguiente: en la que (R1 es un ...

An alkyl ether derivative represented by the formula: wherein R R R R m and n are as defined in the specification or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore the combination according to the present invention is useful as a method for improving cerebral function. Further a pharmaceutical composition containing the compound relating to the combination according to the presen...