The present invention relates to a (2R, 3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process.

The present invention relates to a pharmaceutical formulation comprising tapentadol and cyclodextrin. The invention further relates to a process for producing said pharmaceutical formulations. Finally, the invention relates to the use of cyclodextrin for producing a tapentadol-containing pharmaceutical formulation, wherein the pharmaceutical formulation has a dissolution of at least 0% after 15 min.

The invention relates to a pharmaceutical patch for transdermal administration of the pharmacologically active ingredient Tapentadol or a physiologically acceptable salt thereof, the patch comprising a surface layer, an adhesive layer which comprises a pressure sensitive adhesive and at least a portion of the total amount of the pharmacologically active ingredient that is contained in the pharmaceutical patch, and a removable protective layer, wherein the adhesive layer is located between the su...