The invention relates to a xenon-based anesthetic gas composition to be used via inhalation to maintain or preserve cerebral perfusion during an endarterectomy involving the clamping of the carotid artery in a mammal under general anesthesia. The xenon is preferably used in combination with at least one injectable anesthetic morphine agent such as remifentanil sulfentanil fentanyl and alfentanil. Advantageously the xenon is mixed with an oxygen-containing gas and administered to the patient afte...

A shivering suppressor which is capable of suppressing shivering occurring after dosing with an anesthetic said anesthetic being remifentanil or a pharmaceutically acceptable salt thereof and said shivering suppressor comprising naloxone or a pharmaceutically acceptable salt thereof as the active ingredient; and an anesthetic comprising as the active ingredients remifentanil or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof.

The invention relates to a method for producing N-phenyl-N-(4-piperidinyl)amide salts, particularly pharmaceutically tolerable addition salts of the compound Remifentanil, in that a compound of the formula (III) is reacted with an acrylic acid alkyl ester of the formula CH2-CH-C(O)-OR: where independently of each other R denotes low-molecular alkyl, preferably (C1-4)alkyl, preferably methyl or ethyl, R1 denotes low-molecular alkyl, preferably (C1-4)alkyl, preferably methyl or ethyl

An alternate process for synthesizing opiate or opioid analgesics and anesthetics and intermediates thereof is provided. In particular a process of synthesizing synthetic opiate or opioid compounds such as for example remifentanil carfentanil sufentanil fentanyl and alfentanil are disclosed.