The present invention relates to a rivastigmine-containing patch having improved storage stability and proper release property.

The present invention provides the preparation method for (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate (formula X compound), the preparation methods for its intermediates (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium(formula VI compound), (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium(formula VIII compound) and (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium (formula IX compound), as well a...

The present invention provides the preparation method for (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate (formula X compound), the preparation methods for its intermediates (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium (formula VI compound), (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium (formula VIII compound) and (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium (formula IX compound), as well...

The present invention provides the preparation method for (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate (formula X compound) the preparation methods for its intermediates (S)-1-(3-methoxyphenyl)-NN-dimethyl-N-((S)-1-phenylethyl)ethanaminium (formula VI compound) (S)-1-(3-hydroxyphenyl)-NN-dimethyl-N-((S)-1-phenylethyl)ethanaminium (formula VIII compound) and (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-NN-dimethyl-N-((S)-1-phenylethyl)ethanaminium (formula IX compound) as well as th...

The purpose of the present invention is to provide a rivastigmine-containing adhesive skin patch which has excellent skin permeability of rivastigmine contained therein and has excellent adhesion performance. The present invention provides an adhesive skin patch comprising a support and an adhesive agent layer arranged on the support, wherein the adhesive agent layer contains at least rivastigmine and/or a pharmaceutically acceptable salt thereof and a specific acrylic adhesive agent. The adhesi...

Provided is a patch which is formed with an adhesive layer that retains a medicine on a support, wherein the adhesive layer contains a thermoplastic elastomer, a non-volatile hydrocarbon oil in an amount of over 50 parts by weight and 800 parts by weight or less with respect to 100 parts by weight of the elastomer, and rivastigmine or a salt thereof, and may further contain a tackifier in an amount of 10 parts by weight or less of the adhesive layer.