The present invention provides a solid dispersion of rufinamide in combination with a pharmaceutically acceptable carrier process for its preparation and pharmaceutical compositions comprising it. The present invention provides a solid dispersion of rufinamide in combination with a pharmaceutically acceptable carrier process for its preparation and pharmaceutical compositions comprising it.

The present invention relates to pharmaceutical compositions comprising rufinamide premix and one or more pharmaceutically acceptable excipients and methods of preparing the same.

The present invention relates to a process for the preparation of rufinamide of formula (I) which process comprises: (i) reacting a 26-difluorobenzylhaIide of formula (II) wherein X is chloride bromide or iodide with an azide to obtain 2-(azidomethyl)-13- difluorobenzene of formula (III); (ii) reacting 2-(azidomethyl)-13-difluorobenzene of formula (III) with methyl propiolate to obtain methyl 1-(26-difluorobenzyl)-1 H-123- triazole-4-carboxylic acid of formula (IV); and (iii) reacting methyl 1-(...

The present invention provides a solid dispersion of rufinamide in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it.

The invention relates to a novel, industrially viable, cost effective process for the preparation of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide commonly known as Rufinamide and intermediates thereof.

The present invention relates to a novel process for preparation of rufinamide (I) comprising: reacting 2,6-difluorobenzyl azide (II) and propiolic acid (III) in a mixture of alcohol and water to produce 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid (IV), esterifying the acid (IV) to ester (V) and treating ester (V) with ammonia. The invention further relates to process for purification of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid (IV), by crystallization from a mix...

The invention relates to a novel industrially viable cost effective process for the preparation of 1-(26-difluorobenzyl)-1H-123-triazole-4-carboxamide commonly known as Rufinamide and intermediates thereof.