Preparing 4-azidobutyric acid amide comprises reacting 4-halobutyric acid amide (I) with an alkali azide in the presence of a phase transfer catalyst. Preparing 4-azidobutyric acid amide comprises reacting 4-halobutyric acid amide of formula (XCH 2CH 2CH 2CONH 2)(I) with an alkali azide in the presence of a phase transfer catalyst. X Cl Br or I.

The present invention provides a method for changing addiction-related behavior of a mammal suffering from addiction to abused drugs such as cocaine nicotine methamphetamine ethanol morphine heroin and combinations thereof. The method includes administering to the mammal an effective amount of a compound increasing central nervous system GABA levels wherein the effective amount is sufficient to diminish inhibit or eliminate behavior associated with craving or use of abused drugs. Said compound m...

The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction.The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof.The present invention also provides a method of treatment of cocaine morphine heroin nicotine amphetamine methamphetamine or ethanol addiction by treating a mammal with an effective amount...

The present invention provides a method for changing addiction-related behavior of a mammal suffering from addiction to abused drugs such as cocaine nicotine methamphetamine ethanol morphine heroin and combinations thereof. The method includes administering to the mammal an effective amount of a compound increasing central nervous system GABA levels wherein the effective amount is sufficient to diminish inhibit or eliminate behavior associated with craving or use of abused drugs. Said compound m...

The present invention provides a method for changing addiction-related behavior of a mammal suffering from addiction to abused drugs such as cocaine nicotine methamphetamine ethanol morphine heroin and combinations thereof. The method includes administering to the mammal an effective amount of a compound increasing central nervous system GABA levels wherein the effective amount is sufficient to diminish inhibit or eliminate behavior associated with craving or use of abused drugs. Said compound m...

Use of 2-methyl-1-(1-piperidinyl)- 1-(2-thienyl) cyclohexane (I) in racemic diasteroisomeric or enantiomeric form in pharmaceutical compositions to limit or inhibit the effects of neurotoxic compounds or those containing neurotoxin is new. (I) is preferably used with \- 1 anticholinergic anticonvulsant or cholinesterase reactivator. Suitable anticholinergics are atropine scopolamine atropine N-oxide dihexyverine and tiemonium methyl sulphate. Suitable anticonvulsants include phenobarbital primi...