Disclosed herein is the process for the preparation of 1-(4-chlorophenyl)-5-isopropyl-biguanide hydrochloride (Proguanil hydrochloride), Formula-I, an antimalarial agent.

Disclosed herein is the process for the preparation of 1-(4-chlorophenyl)-5-isopropyl-biguanide hydrochloride (Proguanil hydrochloride) Formula-I an antimalarial agent.

Proguanil has been found to have rapid and effective killing activity against a variety of disease-causing micro organisms. For example, when applied topically, proguanil is particularly effective against Propionibacterium acnes, a bacteria that causes acne

Proguanil has been found to have rapid and effective killing activity against a variety of disease-causing micro organisms. For example when applied topically proguanil is particularly effective against Propionibacterium acnes a bacteria that causes acne; Corynebacterium minutissimum a bacteria that causes erythrasma Gardnerella vaginalis a bacteria that causes vaginosis; Trichomonas vaginalis a protozoan that causes trichomoniasis and C. albicans a fungus (a form of yeast).

Proguanil has been found to have rapid and effective killing activity against a variety of disease-causing micro-organisms. For example when applied topically proguanil is particularly effective against Propionibacterium acnes a bacteria that causes acne; Corynebacterium minutissimum a bacteria that causes erythrasma Gardnerella vaginalis a bacteria that causes vaginosis; Trichomonas vaginalis a protozoan that causes trichomoniasis and C. albicans a fungus (a form of yeast).