A fixed ratio low dose combination of benazepril and a thiazide diuretic is useful for treating hypertension particularly having about 4-6 mg of benazepril hydrochloride and about 5-7.5 mg of hydrochlorothiazide per dosage form. Suitable alternative thiazide derivatives are bendroflumethiazide chlorthalidone chlorothiazide hydroflumethiazide methylchlorothiazide polythiazide trichlormethiazide benzthiazide and cyclothiazide.

PURPOSE: To prepare a composition comprising bezenapril or its salt and a thiazide diuretic agent and capable of treating a lesser degree to a medium degree of hypertension in a lower dose than that when used alone. CONSTITUTION: This composition comprises bezenapril in about 4-6mg preferably about 5mg dose at a time or its pharmaceutically permissible salt and a thiazide diuretic agent in an amount of 80-120% preferably 100% based on 1/8 of the minimal antihyopertensive initial dose recommended...

PURPOSE: To prepare a composition comprising bezenapril or its salt and a thiazide diuretic agent and capable of treating a lesser degree to a medium degree of hypertension in a lower dose than that when used alone. CONSTITUTION: This composition comprises bezenapril in about 4-6mg preferably about 5mg dose at a time or its pharmaceutically permissible salt and a thiazide diuretic agent in an amount of 80-120% preferably 100% based on 1/8 of the minimal antihyopertensive initial dose recommended...

PURPOSE: To prepare a composition comprising bezenapril or its salt and a thiazide diuretic agent and capable of treating a lesser degree to a medium degree of hypertension in a lower dose than that when used alone. CONSTITUTION: This composition comprises bezenapril in about 4-6mg preferably about 5mg dose at a time or its pharmaceutically permissible salt and a thiazide diuretic agent in an amount of 80-120% preferably 100% based on 1/8 of the minimal antihyopertensive initial dose recommended...

Dipeptides and amino acids of the formula A-E-G are disclosed wherein A is e.g. hydrogen or a- RbCO or RbSO2- where Ra and Rb are e.g. alkyl cycloalkyl or aryl;whereinR' is e.g. alkyl;n is 0 1;R2 is e.g. hydrogen or alkyl;R3 is OH NH2are e.g. alkyl;R4 is e.g. hydrogen or alkylR6 is H or methyl;R7 is e.g. hydrogen or alkyl;R8 is e.g. hydrogen methyl or cycloalkyl such that when R8 is cycloalkyl R6 and R7 are hydrogen;R9 is e.g. hydroxy.The compounds have enzyme inhibitor activity e.g. renin inhib...