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XU XUENONG(4)
SUZHOU MINGYUE MEDICAL TECHNOLOGY CO LTD(4)
FRESENIUS KABI ONCOLOGY LTD [IN](2)
TISENI PAOLO SIMONE [IT](2)
BILJAN TOMISLAV [HR](2)
ALPHORA RES INC [CA](1)
AVRA LAB PRIVATE LTD [IN](1)
ALLA RAMA RAO VENKATA [IN](1)
RAMARAO CHANDRASHEKAR [IN](1)
MICHEL PATRICK THOMAS [IN](1)
专利信息
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[药品] 包含 'Pralatrexate'
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条记录, 当前第1/2页。
公开号
公开日
申请号
申请日
1.
WO2014016740A3
2014/3/20
专利标题
:Improved process for the preparation of pralatrexate
专利权人
:
Fresenius Kabi Oncology Ltd.
;
An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful for the preparation of Pralatrexate. The present invention also relates to a substantially pure Pralatrexate and a process for obtaining the same in high yield.
2.
WO2014020553A1
2014/2/6
WO2013IB56285
2013/7/31
专利标题
:SALTS OF PRALATREXATE
专利权人
:
FRESENIUS KABI ONCOLOGY LTD [IN]
;
The present invention provides salts of Pralatrexate, in particular, sodium, lithium and potassium salts and their polymorphic forms, process for the preparation thereof, pharmaceutical compositions comprising these salts and at least one pharmaceutically acceptable excipient, and the use of pharmaceutical composition for the treatment of conditions related to human tumors.
3.
WO2014016740A2
2014/1/30
WO2013IB55912
2013/7/18
专利标题
:IMPROVED PROCESS FOR THE PREPARATION OF PRALATREXATE
专利权人
:
FRESENIUS KABI ONCOLOGY LTD [IN]
;
An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful for the preparation of Pralatrexate. The present invention also relates to a substantially pure Pralatrexate and a process for obtaining the same in high yield.
4.
WO2013177713A1
2013/12/5
WO2013CA50419
2013/5/31
专利标题
:PROCESS FOR PREPARATION OF AN ANTIFOLATE AGENT
专利权人
:
ALPHORA RES INC [CA]
;
The specification relates to a process for preparation of an antifolate compound of formula 7, such as Pralatrexate. Also, disclosed are intermediates and processes for preparation of intermediates useful in the preparation of the antifolate compound. The substituents Y, Z, R, R1 and R2 are as described herein. The processes and intermediates can provide an alternate route to the synthesis of the antifolate compound. Further, the processes can help to avoid distillation or evaporation of high bo...
5.
WO2013164856A1
2013/11/7
WO2013IN00284
2013/4/29
专利标题
:A PROCESS FOR PREPARING INTERMEDIATES OF 10-PROPARGYL-10-DEAZAAMINOPTERIN (PRALATREXATE) SYNTHESIS AND THE INTERMEDIATES THEREOF
专利权人
:
AVRA LAB PRIVATE LTD [IN]
;
ALLA RAMA RAO VENKATA [IN]
;
RAMARAO CHANDRASHEKAR [IN]
;
MICHEL PATRICK THOMAS [IN]
;
NITLIKAR LAKSHMIKANT HANUMANTHRAO [IN]
;
KALAM BHUPATHI REDDY [IN]
;
DUDUKA RAMPRASAD [IN]
;
A process for preparation of 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid and other key intermediates in synthesis of 10-propargyl-10-deazaaminopterin (Pralatrexate) and the intermediates thereof. The 10-propargyl-10-deazaaminopterin (Pralatrexate) is obtained by peptide formation and ester hydrolysis of the intermediate compound 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid by methods known in the art.
6.
CN103275080A
2013/9/4
CN20131199544
2013/5/27
专利标题
:Pralatrexate preparation method
专利权人
:
SUZHOU MINGYUE MEDICAL TECHNOLOGY CO LTD
;
XU XUENONG
;
7.
CN103274962A
2013/9/4
CN20131196967
2013/5/24
专利标题
:N-[4-(1-(2-propinyl)-3, 4-dioxo-n-butyl) benzoyl]-L-glutamic dialkyl ester and preparation method thereof
专利权人
:
SUZHOU MINGYUE MEDICAL TECHNOLOGY CO LTD
;
XU XUENONG
;
8.
CN103274943A
2013/9/4
CN20131196966
2013/5/24
专利标题
:4-[1-(2-propinyl)-3, 4-dioxo-n-butyl] benzoate and preparation method thereof
专利权人
:
SUZHOU MINGYUE MEDICAL TECHNOLOGY CO LTD
;
XU XUENONG
;
9.
CN103265544A
2013/8/28
CN20131199675
2013/5/27
专利标题
:Preparation method of Pralatrexate
专利权人
:
SUZHOU MINGYUE MEDICAL TECHNOLOGY CO LTD
;
XU XUENONG
;
10.
WO2013096800A1
2013/6/27
WO2012US71306
2012/12/21
专利标题
:PROCESSES AND INTERMEDIATES FOR PREPARING PRALATREXATE
专利权人
:
PLUS CHEMICALS S A [CH]
;
TEVA PHARMA [US]
;
TISENI PAOLO SIMONE [IT]
;
GALLUZZO CHRISTIAN [IT]
;
CANAVESI AUGUSTO [IT]
;
BILJAN TOMISLAV [HR]
;
Processes for preparing and purifying Pralatrexate are described in the present application, as well as intermediates in these processes, and salts and solid state forms of the Pralatrexate intermediates.
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