PURPOSE: A solid nanodispersion of pranlukast is provided to improve solubility, to prevent recrystallization after the solid nanodispersion is redispersed in a solvent, and to increase initial dissolution rate, thereby showing equal or better effects using a small amount of pranlukast. CONSTITUTION: A method for preparing a solid nanodispersion of pranlukast comprises the steps of: uniformly mixing 1g of pranlukast, 0.5-2.0 g of a soluble polymer, and 0.1-3 g of a poloxamer surfactant

PURPOSE: A method for preparing a pranlukast nano solid dispersant is provided to improve solubility and thermodynamic stability and to suppress recrystallization. CONSTITUTION: A method for preparing a pranlukast nano solid dispersant comprises: a step of uniformly mixing 1g of pranlukast, 2-6g of polyethylene glycol, and 0.1-3g of poloxamer surfactant

Disclosed is a pranlukast solid dispersion composition with an improved and a method of manufacturing the same. More particularly, the present invention provides a pranlukast solid dispersion manufactured by a hot-melting process using a composition comprising pranlukast and at least one water-soluble polymer selected from the group consisting of polyvinylpyrrolidone vinylacetate copolymer, polyvinylpyrrolidone and polyvinylalcohol, which has greatly improved dissolution rate and bioavailability...

PROBLEM TO BE SOLVED: To provide a tablet containing pranlukast hydrate solving the problems of conventional technique improving the cohesive aggregation of pranlukast hydrate to enable stable continuous tableting using a medicinal composition containing smallest possible amount of diluent binder etc. keeping stable solubility during the production and storage of the preparation and enabling accurate elution control.SOLUTION: The tablet at least contains pranlukast hydrate a binder excluding a h...

PROBLEM TO BE SOLVED: To provide a spray-dried granule comprising pranlukast and to provide a method for producing the granule.SOLUTION: The spray-dried granule comprises the pranlukast and is composed of the pranlukast a water-soluble polymer and a surfactant. The average particle size of the pranlukast in the granule is 0.5-20 .mu.m. The method for producing the spray-dried granule is provided. Thereby not only adhesion cohesiveness and solubility of the pranlukast but also elution rate and bi...