The present invention relates to a process for the preparation of primidone. It also relates to compositions comprising primidone of desired particle size distribution processes for the preparation of such particles and processes for the preparation of the compositions.

Use of 2-methyl-1-(1-piperidinyl)- 1-(2-thienyl) cyclohexane (I) in racemic diasteroisomeric or enantiomeric form in pharmaceutical compositions to limit or inhibit the effects of neurotoxic compounds or those containing neurotoxin is new. (I) is preferably used with \- 1 anticholinergic anticonvulsant or cholinesterase reactivator. Suitable anticholinergics are atropine scopolamine atropine N-oxide dihexyverine and tiemonium methyl sulphate. Suitable anticonvulsants include phenobarbital primi...

NEW MATERIAL:The compound of formula (X is O or H; the substituent groups of the benzene ring are m- or p-positions with each other).EXAMPLE: m-(Succinimidoxyadipoylamino)phenobarbital.USE: Raw material for the preparation of enzyme-labeled hapten and hapten antigen of phenobarbital or primidone is the body fluid. It has constant activity and excellent storage stability and reactivity.PREPARATION: The compound of formula can be prepared by reacting an adipic acid monoester with amino-substituted...

NEW MATERIAL:Succinic acid amide derivatives of formula I (D is formula II III IV and V).EXAMPLE: 3-[ 4-[ 2-( 3-Methyl-25-pyrrolidinedion-3-yl )ethyl ]phenylcarbamoyl ] propionic acid.USE: An intermediate of hapten antigen used to obtain antiserum.PREPARATION: An amino derivative of hapten given as D-NH(sub 2) is made to react with succinic anhydride in an inert solvent such as pyridine at room temperature to the boiling point of the solvent for 30min to 2 days to obtain the compound of formula ...

1243991. CNS depressants. IMPERIAL CHEMICAL INDUSTRIES Ltd. 4 Sept. 1969 [10 June 1968] No. 27501/68. Heading A5B. [Also in Division C2] Pharmaceutical compositions suitable for oral or parenteral administration and having depressant activity on the central nervous system and thymoleptic activity contain novel piperidine piperazine or morpholine derivatives of the formula wherein A is -O- -CH 2 - or =NCOR where R is H alkyl aryl halogenoaryl alkoxy aryloxy arolkloxy or amino and X is phenyl whi...