The present invention relates to the provision of a pharmaceutical composition for use in the treatment of status epilepticus or a method for treating status epilepticus. The present invention provides a pharmaceutical composition for use in the treatment of status epilepticus, which comprises a GABA agonist and perampanel or a pharmacologically acceptable salt or hydrate thereof.

The present invention relates to a process for the synthesis of 2- cyanophenylboronic acid and the esters and salts thereof of formula (II), which are intermediates of the synthesis of active pharmaceutical ingredients such as Perampanel or E2040. formula (II): (II).

The present invention provides novel crystalline forms of perampanel, pharmaceutical compositions comprising same, methods for their preparation and uses thereof for treating seizures and epilepsy.

PROBLEM TO BE SOLVED: To provide an alternative process for preparation of 2-alkoxy-5-(pyridin-2-yl)pyridine or a salt thereof, making it possible to overcome at least partially the drawbacks of the conventional technology.

Methods for the synthesis of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula I or salts thereof are provided.

Methods for the synthesis of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula I or salts thereof are provided.

The present invention relates to a process for synthesising 2-alkoxy-5-(pyridin-2-yl)pyridine which is an intermediate of the synthesis of the active substance Perampenel.

The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula a salt thereof or hydrates thereof. In the formula Q indicates NH O or S; and R R R R and R are the same as or different from each other and each indicates hydrogen atom a halogen atom a C1-6 alkyl group or a group represented by the formula -X-A (wherein X indicates a single bond an optionally sbutituted C1-6 alk...

The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula a salt thereof or hydrates thereof. In the formula Q indicates NH O or S; and R R R R and R are the same as or different from each other and each indicates hydrogen atom a halogen atom a C1-6 alkyl group or a group represented by the formula -X-A (wherein X indicates a single bond an optionally sbutituted C1-6 alk...