ABSTRACT - 600243 The disclosure relates to an agent consisting of theobromine and a decongestant as a combined preparation for use in a therapy of cough wherein the agent is manufactured for administration by an oral route wherein the decongestant is selected from ephedrine levmetamfetamine naphazoline oxymetazoline phenylephrine phenylpropanolamine propylhexedrine pseudoephedrine synephrine and tetrahydrozoline and wherein the decongestant preferably pseudoephedrine is to be administered in a ...

PROBLEM TO BE SOLVED: To provide a drug for treatment of rhinitis which has enhanced convenience of drug treatment utilizing an antihistamine drug and a nasal decongestant.

A method in which a crude chlorinated product of a phenylpropanolamine preferably prepared by reacting thionyl chloride with the phenylpropanolamine is purified by contacting an aqueous solution of the crude product with carbon. The carbon-treated solution of the crude chlorinated product of a phenylpropanolamine is catalytically hydrogenated to the corresponding amphetamine derivative.

A method in which a crude chlorinated product of a phenylpropanolamine preferably prepared by reacting thionyl chloride with the phenylpropanolamine is purified by contacting an aqueous solution of the crude product with carbon. The carbon-treated solution of the crude chlorinated product of a phenylpropanolamine is catalytically hydrogenated to the corresponding amphetamine derivative.

The present invention provides synthetic immunochemical haptens for the generation of antibodies that are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants with insignificant cross-reactivity to endogenous substrates (e.g. dopamine) or over-the-counter medications (e.g. 1-methamphetamine pseudoephedrine phenylpropanolamine and ephedrine). These monoclonal antibodies and their antigen binding fragments are useful in treatment plans for recovering addi...

A process for making an amphetamine from a phenylpropanolamine salt the process comprising: (a) acylating the phenylpropanolamine salt with an acylating agent in a solvent at elevated temperature to make a reaction mixture containing an O-acylated phenylpropanolamine salt which can be isolated by the addition of a crystallization solvent or optionally this mixture can be used in the next step; and (b) hydrogenating the O-acylated phenylpropanolamine salt to make the amphetamine in thepresence of...

A process for making compound of formula Ifrom a phenylpropanolamine salt of formula IIwherein:R1 is hydrogen or a lower alkyl group;each R2 is independently a hydrogen halogen lower alkyl group lower alkoxy groups lower alkyl group substituted with 1 to 5 halogens lower alkoxy groups substituted with 1 to 5 halogens or both R2 together when on adjacent carbons constitute a -O(CH2)xO- where x is 1 to 4 thereby forming a ring structure fused with the phenyl group;R3 is a C1-C8-alkyl group a C1-C1...

A process for making an amphetamine from a phenylpropanolamine salt the process comprising: (a) acylating the phenylpropanolamine salt with an acylating agent in a solvent at elevated temperature to make a reaction mixture containing an O-acylated phenylpropanolamine salt which can be isolated by the addition of a crystallization solvent or optionally this mixture can be used in the next step; and (b) hydrogenating the O-acylated phenylpropanolamine salt to make the amphetamine in thepresence of...

The invention includes synthetic immunochemical haptens for the generation of antibodies the antibodies and the medical treatment applications for using the antibodies. The antibodies are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants and will have insignificant cross-reactivity with endogenous substrates (e.g. dopamine) or over-the-counter medications (e.g. 1-methamphetamine pseudoephedrine phenylpropanolamine and ephedrine). These monoclonal ant...

A process for making an amphetamine from a phenylpropanolamine salt the process comprising: (a) acylating the phenylpropanolamine salt with an acylating agent in a solvent at elevated temperature to make a reaction mixture containing an O-acylated phenylpropanolamine salt which can be isolated by the addition of a crystallization solvent or optionally this mixture can be used in the next step; and (b) hydrogenating the O-acylated phenylpropanolamine salt to make the amphetamine in thepresence of...