The present invention discloses the synthone of Formula (I), wherein R1 and R2 are the same or different and represent independently hydrogen atom or hydroxyl protecting group, and its use for preparation of 19-nor vitamin D derivatives of general Formula (IV), wherein represents single or double bond, p represents an integer 0 to 3, R1 and R2 represent independently hydrogen atom or hydroxyl protecting group, R3 represents hydrogen atom, CH3 or hydroxyl group, R4, R5 and R6 represent independen...

Indene derivatives that are utilizable as intermediates in the synthesis of the vitamin D2 derivative paricalcitol, which is useful as pharmaceutical are efficiently prepared by subjecting a vitamin D2 derivative such as 25-hydroxyvitamin D2 to a two-steps oxidation reaction using an oxidizing agent such as potassium permanganates and sodium periodate in a suitable solvent such as methanol and ethanol.

The present invention relates to a compound and a novel process for the preparation of Paricalcitol intermediates.

Paricalcitol a synthetic vitamin D analog is purified to a purity greater than 99.7% by crystallization from solution in isopropyl acetate solvent followed by filtration and vacuum drying. Isopropyl acetate appears to be unique among commonly available and pharmaceutically acceptable solvents in its ability to precipitate paricalcitol in this high purity essentially free of isomers thereof. In addition paricalcitol of purity of at least 99.9% has been shown to have exceptional storage stability....

The present invention is directed to novel processes for the preparation of paricalcitol to novel intermediates used in these processes, and to processes for preparation of the novel intermediates.

The present invention is directed to novel processes for the preparation of paricalcitol to novel intermediates used in these processes and to processes for preparation of the novel intermediates.