An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.

An acid addition salt of a nortriptyline-GABA conjugate a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders and in the treatment of pain in particular are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.

PROBLEM TO BE SOLVED: To provide an antidepressant which achieves high therapeutic effect in a shorter period and can be safely used without any adverse effect. SOLUTION: The pharmaceutical composition for treating/preventing depression includes an earthworm dry powder as an active ingredient. For treating/preventing depression the pharmaceutical composition can be used alone or used in combination with one or more antidepressants selected from the group consisting of clomipramine nortriptyline...

An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.

The present invention provides a method of promoting bone growth in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.

A method for treating coronavirus infection by administering to a subject in need of the treatment an effective amount of one or more of the following compounds: aklavin sanguinarine amiodarone chlorpromazine clomiphene dihydroergotamine dipyridamole emetine ephedrine prochlorperazine promazine propiomazine aminacrine fluphenazine fenoterol peruvoside proglumide atenolol nerifolin nefopam cycloheximide avermectin B1 bepridil cinnarizine ethisterone pararosaniline methylbenzethonium niclosamide p...

1. A method of administering a drug for which the major clearance mechanism in humans is CYP2D6 (CYP-cytochrome P-450) mediated oxidative biotransformation or a pharmaceutically acceptable salt thereof in combination with a CYP2D6 inhibitor or a pharmaceutically acceptable salt thereof to a human in need of the intended pharmaceutical activity of such drug wherein said drug for which the major clearance mechanism in humans is CYP2D6 mediated oxidative biotransformation is selected from the group...

Immunoassay methods and reagents for the specific quantification of amitriptyline or nortriptyline in a test sample are disclosed employing antibodies prepared with amitriptyline or nortriptyline derivatives of formula (III) wherein for amitriptyline R is CH3 and for nortriptyline R is H. The present invention also describes the synthesis of unique fluorescein tracers of the structure of formula (IV) and formula (V) wherein for a specific amitriptyline immunoassay W1 is a heteroatom linked to th...

PROBLEM TO BE SOLVED: To prepare a blood serum sample for accurately measuring nortripterin.SOLUTION: A blood serum sample for measuring nortripterin is added to a washed chromatographic column this column is washed with an about 70% 0.1-M sodium acetate solution (pH about 4.2) about 30%-acetonitrile and about 5-mM heptane sulfonate a nortripterin metabolite is practically removed from the column and about 50%-acetonitrile about 25%-methanol and about 25% 5-mM K(sub 2) HPO(sub 4) (pH about 7) ar...

Immunoassay methods and reagents for the specific quantification of amitriptyline or nortriptyline in a test sample are disclosed employing antibodies prepared with amitriptyline or nortriptyline derivatives of the Formula III: III wherein for amitriptyline R is CH3 and for nortriptyline R is H. The present invention also describes the synthesis of unique fluorescein tracers of the structure of Formula IV and Formula V: yline immunoassay W1 is a heteroatom linked to the aromatic ring at...