Described are compounds and methods useful for selectively targeting cancer stem cells. The compounds preferentially induce differentiation and/or reduce the proliferation of cancer stem cells relative to normal stem cells. Compounds useful for selectively targeting cancer stem cells include polyene macrolides such as Nystatin or Amphotericin B analogs thereof and pharmaceutically acceptable salts thereof.

The present invention provides a compound which is a nystatin derivative having an additional double bond present between C28 and C29 and which is further modified relative to nystatin at one or more of positions C5 C7 C9 C10 C11 C16 or at the amino group of mycosamine.

The present invention provides a compound which is a nystatin derivative having an additional double bond present between C28 and C29 and which is further modified relative to nystatin at one or more of positions C5, C7, C9, C10, C11, C16 or at the amino group of mycosamine.

The present invention provides a compound which is a nystatin derivative having an additional double bond present between C28 and C29 and which is further modified relative to nystatin at one or more of positions C5 C7 C9 C10 C11 C16 or at the amino group of mycosamine.

Several terpene glycosides (e.g. mogroside V paenoiflorin geniposide rubusoside rebaudioside A steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds including but not limited to paclitaxel camptothecin curcumin tanshinone HA capsaicin cyclosporine erythromycin nystatin itraconazole celecoxib clofazimine digoxin oleandrin nifedipine and amiodarone. The use of the diterpene glycoside rubusoside and monoterpene...