An olmesartan medoxomil preparation method the method comprising the step of deprotecting a compound of formula V in an organic solvent containing p-toluenesulphonic acid the compound of formula V having a structure as shown in the specification. The method of the present invention uses cheap and readily available raw materials and has a moderate reaction condition high reaction selectivity high yield and few by-products thus being suitable for industrialized production.

The present invention provides a novel method to obtain olmesartan medoxomil (I) with a particle size distribution of less than 30 mum comprising: dissolving olmesartan medoxomil (I) in a solvent; adding seed crystals of olmesartan medoxomil (I) followed by isolation.

A pharmaceutical tablet containing olmesartan medoxomil and amlodipine besylate which has improved dissolvability. The composition contains (A) olmesartan medoxomil and (B) amlodipine besylate as active ingredients and (C) a calcium-containing additive. A method for treating or preventing hypertension by administering the pharmaceutical tablet to a patient.

The present invention provides micronized particles of Olmesartan Medoxomil having d0.9 value less than 10µm. Further the present invention provides an easy fast cost effective and reliable process of direct compression or dry granulation for preparation of pharmaceutical composition comprising therapeutically effective amount of Olmesartan Medoxomil having d0.9 less than 10µm.

A pharmaceutical tablet containing olmesartan medoxomil and amlodipine besylate which has improved dissolvability. Said composition contains (A) olmesartan medoxomil and (B) amlodipine besylate as active ingredients and (C) a calcium-containing additive. A method of improving the dissolution properties of a pharmaceutical composition containing olmesartan medoxomil and amlodipine besylate by using said composition is also provided.

The present invention provides micronized particles of Olmesartan Medoxomil having d0.9 value less than 10µm. Further the present invention provides an easy fast cost effective and reliable process of direct compression or dry granulation for preparation of pharmaceutical composition comprising therapeutically effective amount of Olmesartan Medoxomil having d0.9 less than 10µm.