The invention provides solution compositions comprising olopatadine and a PDE4 inhibitor compound of Formula (I). The invention also provides methods for treating allergic and inflammatory diseases. More particularly the present invention relates to formulations of olopatadine and their use for treating and/or preventing allergic or inflammatory disorders of the eye nose skin and ear.

A process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.

A process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.

A methodology for administering topical formulations of olopatadine for treatment of allergic or inflammatory disorders of the nose in children is disclosed. Moreover, an ophthalmic product is provided for practicing the methodologies.

The present invention provides a percutaneously absorptive preparation for preventing or treating allergic eye disease which comprises olopatadine or a salt thereof as an active ingredient. In addition the present invention provides a method for preventing or treating allergic eye disease which comprises applying a percutaneously absorptive preparation comprising olopatadine or a salt thereof to the skin surface including the skin surface of an eyelid thereby casing transfer of a therapeutically...

A methodology for administering topical formulations of olopatadine for treatment of allergic or inflammatory disorders of the nose in children is disclosed. Moreover an ophthalmic product is provided for practicing the methodologies.

Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II) wherein Y is OR1 wherein R1 is C1-C7 alkyl C3-C7 cycloalkyl aryl or heterocycle; or NR2R3 wherein R2 and R3 independently from each other are C1-C7 alkyl aryl or R2 and R3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members obtained by means of a process comprising reacting the corresponding ester or amide of 611-dihydro-11-oxodibenz[be]oxepin-2-a...