FIELD: medicine pharmaceutics.SUBSTANCE: pharmaceutical composition for the reduction of a primary radiation response and an early transient incapacity containing ondansetron and gastrozepin in mass ratio 1-12:2-15; the composition is used as an injectable dosage form.EFFECT: what is developed is the new composition.3 cl 3 tbl 2 dwg

The present application discloses chemical compositions and methods for enhancing the transdermal permeation of therapeutic agents through skin. The chemical compositions and methods of the invention can include combinations of a first fatty acid having about 14 or more carbon atoms and a second fatty acid having about 10 or less carbon atoms. These compositions are useful for the delivery of therapeutic agents in particular hard to deliver drugs such as those that have fused rings including ond...

The invention includes compositions for transmucosal administration to an animal comprising at least one active agent and a pharmaceutically acceptable carrier. A preferred active agent is selected from the group consisting of meloxicam carprofen enrofloxacin clemastine diphenhydramine digoxin levothyroxine cyclosporine ondansetron lysine zolpidem propofol nitenpyram ivermectin milbemycin and pharmaceutically acceptable salts solvates and esters thereof. In another embodiment the invention inclu...

DRUG DELIVERY SYSTEMS COMPRISING WEAKLY BASIC DRUGS AND ORGANIC ACIDS Abstract There is disclosed a pharmaceutical dosage form such as a capsule a conventional or orally disintegrating tablet capable of delivering a nitrogen (N)-containing therapeutic agent having a pKa in the range of from about 5 to 14 into the body in a sustained-released fashion in order to be suitable for a twice- or once-daily dosing regimen comprising at least one organic acid which solubilizes the therapeutic agent the d...