The invention relates to a pharmaceutical composition comprising an inert core coated with a first layer and a second layer the first layer being between the core and the second layer the first layer comprising a mixture of naltrexone hydrochloride and a stabilizer and the second layer comprising a hydrophobic material wherein one or more coated cores are included in a dosage form to provide a total of about 20 mg or less naltrexone hydrochloride said stabilizer is in an effective amount to inhi...

Method for producing nalmefene hydrochloride from naltrexone which method is particular well adapted for large-scale industrial application and has been found to be efficient to give a high yield and to afford highly pure nalmefene hydrochloride salt.

This invention relates to treatment of epithelial wounds. In particular the invention relates to methods and formulations for treating epithelial wounds based on application of an opioid antagonist such as naltrexone.

Methods are provided which include converting oripavine to other opiates including converting oripavine to naltrexone buprenorphine 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included.

FIELD: biotechnologies.SUBSTANCE: invention provides hemihydrate of naltrexone base that has characteristic peaks at powder X-ray diffraction pattern at the angles 2? 7.1 9.4 12.7 13.5 14.3 14.9 16.9 21.6 22.2 24.2 25.6 and 27.7°. Moreover the invention pertains to the method of its obtaining as well as to the method of obtaining microspheres containing naltrexone base.EFFECT: hemihydrate of naltrexone base with high solvability in organic solvents simplified and cheap method for obtaining polym...

The present disclosure relates to compositions kits uses systems and methods for treating overweight and obesity using naltrexone plus bupropion preferably in combination with a comprehensive web-based and/or telephone-based weight management program and preferably in subjects at increased risk of adverse cardiovascular outcomes.

Disclosed are compositions uses methods and kits for increasing drug bioavailability in a naltrexone therapy.

This invention pertains to pharmaceutical composition comprising a plurality of multi-layered beads having an oxycodone layer and a sequestering subunit comprising a naltrexone and a blocking agent in particular pharmaceutical compositions comprising a higher level of naltrexone and related compositions and methods of use such as in the prevention of abuse of a therapeutic agent. The compositions of the present invention also have a long T max for oxycodone release and a flatter release profile ...