PROBLEM TO BE SOLVED: To provide a gray hair inhibitor capable of promoting strongly melanogenesis in melanocyte by acting on the melanocyte and usable for a long period. SOLUTION: This gray hair inhibitor contains as an active ingredient a compound selected from allantoin or salts thereof ethenzamide phenylephrine or salts thereof guaifenesin sulfamethoxazole retinol palmitate bisacodyl neostigmine or salts thereof and resorcin. COPYRIGHT: (C)2013JPO&INPIT

FIELD: medicine pharmaceutics. ^ SUBSTANCE: invention refers to chemistry and pharmaceutics namely an improved method for preparing iodide or methylsulphate neostigmine which can find application as drugs. The method involves preparing sodium 3-dimethylaminophenolate enabling its reaction with dimethylcarbamoyl acid chloride and reaction of prepared 3-((dimethylcarbomoyloxy)phenyl)-dimethylamine with an alkylating agent (iodomethane or dimethylsulphate). The method is characterised by the fact t...

PROBLEM TO BE SOLVED: To solve such a problem that an ophthalmic solution compounded with tetrahydrozoline or a salt thereof neostigmine or a salt thereof berberine or a salt thereof chlorpheniramine or a salt thereof vitamin B12 vitamin B6 or salt thereof panthenol taurine chondroitin sulfate or a salt thereof terpenoid glycyrrhizic acid or a salt thereof and an ophthalmic solution additionally compounded with aspartic acid or a salt thereof cause troubles such as gelation or precipitation unde...

Disclosed are 2-imino-36-dimethyl-56-diphenyl-tetrahydropyrimidin-4-one derivatives as represented by the general formula (I) wherein R2 is hydrogen; R1 is methyl; W is C(=O); one of R3 or R4 is hydrogen and the other is an optionally substituted phenyl group; U is C(R6)(R7) where one of R6 or R7 is methyl and the other is an optionally substituted phenyl group; and X is NH. Representative compounds include 2-imino-36-dimethyl-5-(4-trifluoromethylphenyl)-6-(24-difluorophenyl)-tetrahydropyrimidin...

PROBLEM TO BE SOLVED: To obtain a composition having a high ameliorating effect on eyestrain.SOLUTION: The composition for remarkably ameliorating eyestrain comprises pranoprofen or its salt and neostigmine methyl sulfate. The composition is especially useful since it treats eyestrain (especially contact lens wearer) caused by overuse of eyes in a VDT (Visual Display Terminal) operation reading gaze operation observation operation etc. The addition of a specific viscous agent to the composition ...

PROBLEM TO BE SOLVED: To provide a new agent for the treatment of cardiac failure having excellent cardiac function improving action.SOLUTION: The agent for the treatment of cardiac failure contains a cholinesterase inhibitor as an active component. The cholinesterase inhibitor is preferably one or more compounds selected from donepezil tacrine rivastigmine galantamine pyridostigmine and neostigmine or their physiologically permissible salts.COPYRIGHT: (C)2007JPO&INPIT