The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer a galactomannan such as guar and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound.

The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer a galactomannan such as guar and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound.

The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer a galactomannan such as guar and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound.

PROBLEM TO BE SOLVED: To provide a technique that increases the photostability of chlorite contained in an aqueous formulation. SOLUTION: By means of the combined use in an aqueous formulation of chlorite and at least nonsteroidal anti-inflammatory agent selected from the group consisting of bromfenac diclofenac ketorolac flurbiprofen a pharmaceutically acceptable salt thereof and nepafenac it is possible to increase the photostability of chlorite. COPYRIGHT: (C)2013JPO&INPIT

The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer a galactomannan such as guar and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound.

The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer a galactomannan such as guar and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound.

The objective of the present invention is to provide a technique that increases the photostability of chlorite contained in an aqueous formulation. By means of the combined use in an aqueous formulation of chlorite and at least one nonsteroidal anti-inflammatory agent selected from the group consisting of bromfenac diclofenac ketorolac flurbiprofen a pharmaceutically acceptable salt thereof and nepafenac it is possible to increase the photostability of chlorite.

The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer a galactomannan such as guar and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound.

Topical suspension compositions of nepafenac are disclosed. The compositions are especially suitable for topical ophthalmic administration.