PROBLEM TO BE SOLVED: To provide a novel arteriosclerosis drug that controls infiltration of macrophage into an artery and is thereby capable of controlling thickening and fibrosis of aortic tunica media. SOLUTION: The arteriosclerosis drug includes nitroso nifedipine and a nitroso nifedipine derivative such as nitroso-nisoldipine nitroso-nimodipine nitroso-nicardipine and nitroso-nitrendipine nitroso nifedipine as active ingredients. The drug can control infiltration of macrophage into an arte...

The present invention relates to a pharmaceutical dosage form based on an osmotic active ingredient release system comprising an active ingredient combination of nifedipine and/or nisoldipine and at least one angiotensin II antagonist wherein the active ingredient combination undergoes controlled (modified) release in the body and to processes for the production thereof to the use thereof as pharmaceuticals to the use thereof for the prophylaxis secondary prophylaxis and/or treatment of disorder...

ABSTRACT - 596395 The disclosure relates to a solid preparation comprising (i) compound selected from the group consisting of 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid and 2-ethoxy-1-[[2'-(45-dihydro-5-oxo-124-oxadiazol-3-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid or a salt thereof (ii) a sugar alcohol selected from...

The invention relates to a pharmaceutical dosage form comprising an active ingredient combination of nifedipine or nisoldipine and at least one angiotensin-II antagonist and/or at least one diuretic characterized in that nifedipine or nisoldipine are controlled (modified) in the body and the angiotensin-II antagonist and/or the diuretic is quickly released (immediate release (IR)) and to a method for production thereof to the use thereof as a medicine and to the use thereof for prophylaxis secon...

PROBLEM TO BE SOLVED: To provide a novel arteriosclerosis drug that controls infiltration of macrophage into an artery and is thereby capable of controlling thickening and fibrosis of aortic tunica media. SOLUTION: The arteriosclerosis drug includes nitroso nifedipine and a nitroso nifedipine derivative such as nitroso-nisoldipine nitroso-nimodipine nitroso-nicardipine and nitroso-nitrendipine nitroso nifedipine as active ingredients. The drug can control infiltration of macrophage into an arte...

PHARMACEUTICAL DOSAGE FORM COMPRISING NIFEDIPINE OR NISOLDIPINE AND AN ANGIOTENSIN-II ANTAGONIST AND/OR A Abstract The invention relates to a pharmaceutical dosage form comprising an active ingredient combination of nifedipine or nisoldipine and at least one angiotensin-II antagonist and/or at least one diuretic characterized in that nifedipine or nisoldipine are controlled (modified) in the body and the angiotensin-II antagonist and/or the diuretic is quickly released (immediate release (IR)) a...

A method and composition are provided for the treatment of an anorectal disorder and for controlling the pain associated therewith. The method comprises administering to a subject in need of such treatment therapeutically effective amounts of a calcium channel blocker either alone or together with a nitric oxide donor. Amlodipine anipamil barnidipine benidipine bepridil darodipine diltiazem efonidipine felodipine isradipine lacidipine lercanidipine lidoflazine manidipine mepirodipine nicardipine...