The present invention generally relates to the transdermal delivery of various compounds. In some aspects transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ergopeptines triptans and other compounds including salts and derivatives of these and optionally a hostile biophysical environment and/or a nitric oxide donor. In some cases the composition may be stabilized using a combinatio...

The present invention generally relates to the transdermal delivery of various compounds. In some aspects transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising an H1 antihistamine and/or a salt thereof and optionally a hostile biophysical environment and/or a nitric oxide donor. In some cases the composition may be stabilized using a combination of a stabilization polymer (such as xan...

The present invention generally relates to the transdermal delivery of various compounds. In some aspects transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a COX-2 inhibitor and/or a salt thereof and optionally a hostile biophysical environment and/or a nitric oxide donor. In some cases the composition may be stabilized using a combination of a stabilization polymer (such as xanth...

The present invention generally relates to the transdermal delivery of various compounds. In some aspects transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising terbinafine a triazole antifungal drug and/or salts thereof and optionally a hostile biophysical environment and/or a nitric oxide donor. In some cases the composition may be stabilized using a combination of a stabilization po...

The present invention generally relates to the transdermal delivery of various compounds. In some aspects transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof and optionally a hostile biophysical environment and/or a nitric oxide donor. In some cases the composition may be stabilized using a combination of a stabilization pol...

The present invention generally relates to the transdermal delivery of various compositions. In some aspects the transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ibuprofen and/or an ibuprofen salt a nitric oxide donor and optionally a hostile biophysical environment. In some cases the composition may be stabilized using a stabilization polymer such as xanthan gum KELTROL® BT and/...

Abstract The present invention generally relates to the transdermal delivery of substances and in some embodiments to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect various methods for the transdermal delivery of beneficial substances are disclosed. By creating a hostile biophysical environment beneficial substances may be delivered according to certain embodiments through the stratum corneum of the skin into the boly. Beneficial substances ...

The present invention generally relates to the transdermal delivery of substances and in some embodiments to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect various methods for the transdermal delivery of beneficial substances are disclosed. By creating a hostile biophysical environment beneficial substances may be delivered according to certain embodiments through the stratum corneum of the skin into the body. Beneficial substances include b...

The present invention generally relates to the improvement of tissue health by increasing local blood flow. In some aspects of the invention increased local blood flow is effected by the transdermal delivery of the nitric oxide precursor L-arginine and/or its derivatives alone or optionally in conjunction with an adjunct such as theophylline. The transdermal delivery is effected in certain embodiments through the means of a hostile biophysical environment such as that created by a high ionic str...

The present invention generally relates to the improvement of tissue health by increasing local blood flow. In some aspects of the invention increased local blood flow is effected by the transdermal delivery of the nitric oxide precursor L-arginine and/or its derivatives alone or optionally in conjunction with an adjunct such as theophylline. The transdermal delivery is effected in certain embodiments through the means of a hostile biophysical environment such as that created by a high ionic str...