The present invention generally relates to the transdermal delivery of substances and in some embodiments to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect various methods for the transdermal delivery of beneficial substances are disclosed. By creating a hostile biophysical environment beneficial substances may be delivered according to certain embodiments through the stratum corneum of the skin into the body. Beneficial substances include b...

The present invention generally relates to the improvement of tissue health by increasing local blood flow. In some aspects of the invention increased local blood flow is effected by the transdermal delivery of the nitric oxide precursor L-arginine and/or its derivatives alone or optionally in conjunction with an adjunct such as theophylline. The transdermal delivery is effected in certain embodiments through the means of a hostile biophysical environment such as that created by a high ionic str...

The present invention generally relates to the transdermal delivery of various compositions. In some aspects the transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ibuprofen and/or an ibuprofen salt a nitric oxide donor and optionally a hostile biophysical environment. In some cases the composition may be stabilized using a stabilization polymer such as xanthan gum KELTROL� BT and/...

The present invention generally relates to the improvement of tissue health by increasing local blood flow. In some aspects of the invention increased local blood flow is effected by the transdermal delivery of the nitric oxide precursor L-arginine and/or its derivatives alone or optionally in conjunction with an adjunct such as theophylline. The transdermal delivery is effected in certain embodiments through the means of a hostile biophysical environment such as that created by a high ionic str...

The present invention generally relates to the transdermal delivery of various compositions. In some aspects the transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ibuprofen and/or an ibuprofen salt a nitric oxide donor and optionally a hostile biophysical environment. In some cases the composition may be stabilized using a stabilization polymer such as xanthan gum KELTROL� BT and/...

The present invention generally relates to the transdermal delivery of substances and in some embodiments to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect various methods for the transdermal delivery of beneficial substances are disclosed. By creating a hostile biophysical environment beneficial substances may be delivered according to certain embodiments through the stratum corneum of the skin into the body. Beneficial substances include b...

This invention generally relates to improvement of the body and skin appearance for example enhancing the appearance of sagging wrinkled or cellulite-afflicted areas of the skin and body through the local delivery of a nitric oxide donor for example using delivery vehicles such as lotions creams liquids and/or transdermal patches. In some embodiments a delivery vehicle containing a nitric oxide donor for example L-arginine (an important biological precursor) or its derivatives in a sufficient co...

A delivery vehicle and method for delivering either topically or orally a nitric oxide releasing substance such as L-arginine 31 into human or mammalian tissue for the purpose of producing beneficial effects such as the relief of pain the warming of cold tissues the growth of hair on the scalp the healing of leg ulcers the relief of impotence as well as other beneficial effects. The delivery vehicle provides a hostile biophysical environment which facilitates and promotes the migration of the ni...