A medicine composition contains vitamin D and metformin wherein vitamin D comprises vitamin D2 vitamin D3 alphacalcidol calcifediol calcitriol and dihydrotachysterol. The composition can be used in the preparation of a medicine for treating and/or preventing a polyp and cancer in large intestine.

Provided are a composite formulation for oral administration comprising metformin and rosuvastatin and a method for preparing the same. The composite formulation according to the present invention exhibits excellent effects on preventing and treating dyslipidemia and hypercholesterolemia and shows excellent storage stability and thus can be effectively used for treating dyslipidemia and hypercholesterolemia in a diabetic patient.

Provided herein are methods for treating conditions associated with a chemosensory receptor including diabetes obesity and other metabolic diseases disorders or conditions by administrating a composition comprising a chemosensory receptor ligand such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions including bitter receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention. Also provided here...

The present invention relates to compounds having a specified ursolic acid structure wherein R is H or OH and x+ is protonated metformin protonated arginine protonated lysine and protonated meglumine. The invention also relates to intermediates used in the preparation of such compounds processes for the preparation of such compounds and intermediates pharmaceutical compositions comprising such compounds and the methods of treatment using such compounds as antidiabetic antiobesity and antisarcope...

The present invention relates to compounds having the following structure: wherein R is H or OH and X+ is protonated metformin protonated arginine protonated lysine and protonated meglumine. The invention also relates to intermediates used in the preparation of such compounds processes for the preparation of such compounds and intermediates pharmaceutical compositions comprising such compounds and the methods of treatment using such compounds as antidiabetic antiobesity and antisarcopenia agents...

The present invention provides solid preparation superior in disintegration property and preservation stability. The present invention relates to a solid preparation containing (1) compound (A) or a salt thereof (2) metformin or a salt thereof and (3) crospovidone. It also relates to compound (A) or a salt thereof superior in dissolution property.