Certain novel oral antidiabetic compositions are disclosed. These pharmaceutical compositions involve the concomitant use of two different organic chemical compounds each chosen from a separate class of known hypoglycemic agents. One class of agents involves certain known oxazolidine-24-dione compounds (A) while the other class is primarily concerned with a series of known hypoglycemic sulfonylureas (B). Preferred embodiments involve the use of 5-(3-thienyl)oxazolidine-24-dione 5-(4-ethoxy-3-thi...

The present invention relates to a method of preparing N-{4-[2-(5-methyl-pyrazinyl-2-carboxamido)-ethyl]-benzenesulphonyl}-N min -cyclohexylurea or glipizide, which has the chemical structure (I), by letting 4-[2-(5-methylpyrazinyl)-2-carboxamido)-ethyl]-benzenesulphonamide with the chemical structure (II), where R<1> = NH2, react with N-cyclohexyl trichloroacetamide with the chemical structure (III), where R<2> = NHCOCCl3, according to the following reaction scheme: The reaction i...