FIELD: medicine pharmaceutics.SUBSTANCE: there are presented methods of treating or preventing an addiction or recurrent addictive behaviour including: alcohol nicotine marijuana marijuana derivative opioid receptor antagonist benzodiazepine barbiturate and psychostimulant by administering the peroxisome proliferator-activated receptor gamma (PPAR?) agonist thiazolidinedione alone or in a combination with another therapeutic agent - an opioid receptor agonist a mixed partial opioid receptor agon...

The present invention relates to a bilayer tablet formulation providing a concomitant immediate release and controlled release.

Provided herein are drug products with low dose pioglitazone for use in the treatment (e.g. delay of onset) of cognitive impairment of the Alzheimer's type. Methods of manufacture thereof are also provided. Further provided are methods of treatment for Alzheimer's disease including administering a drug product with low dose pioglitazone. The methods may include determining whether the subject is at risk of developing Alzheimer's disease based upon the subject's age and TOMM40 523 genotype.

The present invention provides an oral preparation sufficiently masking the bitter taste of pioglitazone and a salt thereof. The present invention provides an oral preparation containing pioglitazone or a salt thereof and alkali metal chloride.

Provided is an oral agent in particular a solid preparation in which the foul taste of pioglitazone and salts thereof is adequately masked. An oral agent containing pioglitazone or a salt thereof a sweetener and at least two types of flavoring; also a method for suppressing the foul taste of pioglitazone or a salt thereof by using a sweetener and at least two types of flavoring.

PROBLEM TO BE SOLVED: To provide a method for manufacturing 5-ä4-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl}-2 4-thiazolidinedione hydrochloride (pioglitazone hydrochloride) of high purity. SOLUTION: The manufacturing method of pioglitazone hydrochloride includes causing 5-ä4-[2-(5-ethyl-pyridyl)ethoxy]benzyl}-2-imino-4-thiazolidinone (imino isomer) to react with at least one protecting group-introducing agent selected from the group consisting of dialkyldicarbonates and triarylmethyl halides in the p...

Provided herein are drug products with low dose pioglitazone for use in the treatment (e.g. delay of onset) of cognitive impairment of the Alzheimer's type. Methods of manufacture thereof are also provided. Further provided are methods of treatment for Alzheimer's disease including administering a drug product with low dose pioglitazone. The methods may include determining whether the subject is at risk of developing Alzheimer's disease based upon the subject's age and TOMM40 523 genotype.

Provided herein are drug products with low dose pioglitazone for use in the treatment (e.g. delay of onset) of cognitive impairment of the Alzheimer's type. Methods of manufacture thereof are also provided. Further provided are methods of treatment for Alzheimer's disease including administering a drug product with low dose pioglitazone. The methods may include determining whether the subject is at risk of developing Alzheimer's disease based upon the subject's age and TOMM40 523 genotype.