PCT No.PCT/US92/06776 Sec. 371 Date Feb. 24 1994 Sec. 102(e) Date Feb. 24 1994 PCT Filed Aug. 19 1992 PCT Pub.No.WO93/03724 PCT Pub.Date Mar. 4 1993The present invention provides a new composition food product and uses for a known compound.More particularly the present invention provides a new pharmaceutical composition containing 3-guanidinopropionic acid and a method of using 3-guanidinopropionic acid to prevent or treat obesity in non-insulin dependent diabetic (NIDDM) patients that is caused...

The present invention provides a method for treating hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.

The present invention provides a method for making known pharmaceutical compounds. More particularly the present invention provides a new reduction method for making thiazolidinedione derivatives particularly ciglitazone pioglitazone and englitazone. This reduction method comprises reacting a compound of formula (II) with a cobalt ion a ligand and a reducing agent to achieve a compound of formula (I).

The present invention provides a method for treating hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent particularly ciglitazone or pioglitazone.(From WO9112003 A1)

The present invention provides a method for making known pharmaceutical compounds. More particularly the present invention provides a new reduction method for making thiazolidinedione derivatives, particularly ciglitazone, pioglitazone, and englitazone. This reduction method comprises reacting a compound of formula (II) with a cobalt ion, a ligand and a reducing agent to achieve a compound of formula (I).

The present invention provides a method for treating hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.