The invention relates to compounds of formula 1 and to medicaments comprising these compounds further to intermediates of formula 2 and 3.

598728 Disclosed is a sustained-release pharmaceutical dosage form adapted for oral administration to a subject in need thereof comprising a therapeutically effective amount of at least one bile acid sequestrant selected from colesevelam colesevelam hydrochloride and sevelamer a therapeutically effective amount of at least one proton pump inhibitor and a gastric-retention vehicle composition comprising one or more hydrogels wherein said dosage form is adapted for use in preventing or treating an...