PROBLEM TO BE SOLVED: To produce a liquid medicine containing a stabilized azulene derivative by performing deaerating of the liquid medicine containing the azulene derivative and substituting the head space with nitrogen.SOLUTION: This liquid medicine containing a stabilized azulene derivative is obtained by performing deaeration of the liquid medicine containing the azulene derivative to remove oxygen dissolving in the solution packing the oxygen-removed solution into a packing vessel and subs...

The present invention relates to methods and compositions effective in treating, preventing, reducing the severity of, or relieving the symptoms of, Gastro Esophageal Reflux Disease (GERD). The compositions comprise, as an active ingredient, an extract from the plant genus Conyza Less, preferably from the species Conyza bonariensis (L) Cronq. The composition comprises only natural ingredients and has been demonstrated to be safe for use, while still providing a beneficial therapeutic effect. The...

The present invention relates to methods and compositions effective in tr eating, preventing, reducing the severity of, or relieving the symptoms of, Gastro Esophageal Reflux Disease (GERD). The compositions comprise, as an ac tive ingredient, an extract from the plant genus Conyza Less, preferably fro m the species Conyza bonariensis (L) Cronq. The composition comprises only n atural ingredients and has been demonstrated to be safe for use, while still providing a beneficial therapeutic effect....

PURPOSE: To obtain the subject composition having guaranteed bioavailability of the drug without causing the adsorption and trapping of the drug to sucralfate in spite of the formulation of the preparation to compound the drug and sucralfate at the same time.CONSTITUTION: (A) Sucralfate and (B) other drug are compounded in the same preparation to effect the rapid dissolution of the component B without being adsorbed or trapped to the component A. Preferably the compound A is compounded together ...

This invention is directed to new drug delivery systems (SMS packagingTM) and uses thereof of freshly prepared effective high concentrated hygienic pharmaceutical compositions. The new delivery systems including sucralfate is used for treating and preventing oral diseases in mammals. Moreover this invention provides pharmaceutical compositions methods and kits for topical administration to oral ulcers comprising sucralfate (AftapetTMAftakid TM AftakitTM ChemokitTM). This invention is a platform ...

PURPOSE: To obtain a sucralfate pharmaceutical preparation containing a specific organic carboxylic acid and sucralfate increased in adhesion of sucralfate to ulcer part of mucosa and applicable for lower digestive tract as well as ulcer gastric ulcer and duodenal ulcer.CONSTITUTION: The pharmaceutical preparation contains (A) an organic carboxylic acid (preferably malic acid) having >=2 carboxyl groups or hydroxyl groups and (B) sucralfate preferably in a ratio of composition in terms of weight...

The present invention provides compositions and methods for the selective identification of damaged sites in the gastrointestinal tract. More particularly the compositions comprise a phosphated and/or sulfated saccharide such as sucralfate containing one or more optical molecules.

The present invention relates to a pharmaceutical composition comprising sucralfate, aluminium acetate and vitamins having skin wound-healing activity. The composition may also contain glycine, an antibacterial agent (for example, erythromycin, gentamycin, neomycin, colloidal silver, silver sulfadiazine) or an antifungal agent (for example, econazole, miconazole or itraconazole). Said composition is formulated in a form selected from sprays, dermatological powders, gels, ointments, emulsions, dr...