The present disclosure relates to pharmaceutical compositions comprising omeprazole lansoprazole and sodium bicarbonate. Methods of using such compositions are also provided.

The present disclosure relates to pharmaceutical compositions comprising omeprazole lansoprazole and sodium bicarbonate. Methods of using such compositions are also provided.

A orally disintegrating tablet is obtained by tableting fine granules showing controlled release of lansoprazole and an additive which is capable of suppressing breakage of the fine granules during tableting and can control the release of lansoprazole for a long time and can maintain a therapeutically effective concentration for a prolonged time and shows superior disintegration property in the oral cavity.

The present invention relates to a production method of a crystal of (R)-lansoprazole or (S)-lansoprazole which includes crystallization at a temperature of about 0°C to about 35°C from a C1-4 alkyl acetate solution containing (R)-lansoprazole or (S)-lansoprazole at a concentration of about 0.1 g/mL to about 0.5 g/mL and the like. According to the production method of the present invention a crystal of (R)-lansoprazole or (S)-lansoprazole superior in preservation stability can be produced effici...