Omeprazole and lansoprazole which are chemically pyridine-benzimidazole sulfinyl compounds are produced from the corresponding acetamide-sulfide compounds by a process of oxidation to form the amide sulfinyl compound followed by alkaline hydrolysis to the sulfinyl carboxylate or salt and decarboxylation.

Omeprazole and lansoprazole which are chemically pyridine-benzimidazole sulfinyl compounds are produced from the corresponding acetamide-sulfide compounds by a process of oxidation to form the amide sulfinyl compound followed by alkaline hydrolysis to the sulfinyl carboxylate or salt and decarboxylation.(From US5374730 A)

Omeprazole and lansoprazole, which are chemically pyridine-benzimidazole sulfinyl compounds, are produced from the corresponding acetamide-sulfide compounds by a process of oxidation to form the amide sulfinyl compound, followed by alkaline hydrolysis to the sulfinyl carboxylate or salt, and decarboxylation.

Omeprazole and lansoprazole, which are chemically pyridine-benzimidazole sulfinyl compounds, are produced from the corresponding acetamide-sulfide compounds by a process of oxidation to form the amide sulfinyl compound, followed by alkaline hydrolysis to the sulfinyl carboxylate or salt, and decarboxylation.

Intermediate for the synthesis of lansoprazole and procedure for obtaining it. Chemical product of formula I, called 2-[[[1H- benzimidazol-2-yl]thio]methyl]-3-methyl-4-(2,2,2- trifluoroethoxy)pyridine N-oxide, usable as an intermediate for the synthesis of the anti-ulcerative and commercial pharmaceutical active principle called lansoprazole. Procedure for preparation of I from 2,3-dimethyl-4- nitropyridine N-oxide. Procedure for use of product I as an intermediate in the synthesis of lansoprazo...

Procedure for preparing a stable oral pharmaceutical composition.The procedure consists in suspending lansoprazole (formula I) in an aqueous solution of disodium phosphate and sodium laurylsulphate, mixing this with the rest of the excipients, granulating and spheroidising, covering the granulates with a soluble isolating coating and, lastly, covering with an enteric coating.Said composition is useful in treating gastrointestinal diseases.