1. A granulate comprising >= 96 wt % an orally active .beta.-lactam antibiotic having a solubility in water of 1: <= 10. 2. The granulate according to claim 1, characterized in that comprises up to 0.5 wt %, preferably up to 0.1 wt % binding agent for wet granulation or <= 4 wt %, preferably up to 0.5 wt % a film-forming agent, the percentage based on the granulate. 3. A medicament for oral administration comprising the granulate according to claim 1 or 2, microcrystalline cellulose, microfine c...

1. Process for the preparation of a granulate comprising a water soluble orally active -lactam antibiotic including the steps of: a. moistening components making up the granulate with an aqueous solution containing 0-0.5 wt % preferably 0-0.1 wt% of a wet granulation binding agent the percentage based on the granulate; b. screening the wet mass through a 2 mm sieve; c. drying the product obtained in step b.; d. screening the dry product of step c. through an at least 0.71 mm sieve. 2. Process ac...

1. Process for the preparation of a granulate, comprising a water soluble, orally active [beta]-lactam antibiotic, including the steps of: a. moistening components making up the granulate with an aqueous solution containing 0-0.5 wt %, preferably 0-0.1 wt%, of a wet granulation binding agent, the percentage based on the granulate

By the method sodium salts of isoxazolepenicillins: oxacillin, cloxacillin, dicloxacillin flucloxacillin are produced which are betalactamazo- and acid resistant antibiotics and find wide application in the medical practice independently and in combination with other antibiotics. By the method, the sodium salts are in crystalline form without containing any organic solvents and bases.

Storage vessels filled with waste radioactive material are taken underground using the entrance of an operating or abandoned mine. The vessels are deposited in chambers cut into previously undisturbed rock below the 'karst' water level. The chambers are filled and each chamber, section and the whole 'field' is sealed off against water. Transport is always carried out against the flow of ventilation air. The underground storage area is located below the 'karst' water level, in rock formation with...

1422176 Pharmaceutical tablets BEECHAM GROUP Ltd 1 May 1974 [5 May 1973 7 Dec 1973] 21502/73 and 56858/73 Heading A5B Pharmaceutical tablets comprise 10% to 70% by weight of heavy magnesium carbonate, 30% to 85% by weight of a semi-synthetic penicillin or cephalosparin which is suitable for oral administration and 0 to 40% by weight of conventional tabletting ingredients. The tablets may be produced by direct compression in a tablet press. Two different penicillins may be present in the tablets....

1407400 Calcium flucloxacillin compositions BEECHAM GROUP LTD 10 Nov 1972 [25 Nov 1971] 54764/71 Heading A5B [Also in Divisions C2] Pharmaceutical compositions having antibacterial activity comprise a calcium fludoxacillin (3-(2'-chloro-6'-fluorophenyl)5-methyl-4- isoxazolyl penicillin) hydrate e.g. the di- or octa-hydrate and one or more pharmceutically acceptable carrier(s) and/or flavouring materials. The compositions are administered orally and may be in the form of a powder suitable for mix...

1406239 Magnesium flucloxacillin compositions BEECHAM GROUP LTD 10 Nov 1972 [12 Oct 1971] 47414/71 Heading A5B [Also in Division C2] Pharmaceutical compositions having antibacterial activity comprise a magnesium flucloxacillin (3 - (2' - chloro - 6' - fluorophenyl)5- methyl-4-isoxazolylpenicillin) hydrate e.g. the tetra- or octa-hydrate and one or more pharmaceutically acceptable carrier(s) and/or flavouring materials. The compositions are administered orally and may be in the form of a powder s...