1331435 Pyridylmethylcarbonyloxy-blocked amine derivatives RHONE-POULENC SA 4 Aug 1970 [5 Aug 1969 9 June 1970] 37633/70 Headings C2A and C2C [Also in Division C3] Polyfunctional compounds containing one or more amino radicals with at least one of said radicals protected by a group: (where Py is pyridyl or pyridyl N-oxide, optionally substituted by a methyl radical) are prepared by reacting the said polyfunctional compound with Py-CH 2 -OCO-X (where X is a radical which activates the carbonyl gr...

1323362 Polymyxin derivatives RHONEPOULENC SA 4 Aug 1970 [5 Aug 1969] 37632/70 Headings C2A and C2C Novel cyclic polypeptides having the general Formula I wherein Y-Z represents one of the amino acid chains D-Leu-Thr, D-Phe-Leu, D-Leu- Leu and D-Leu-Ileu

The invention relates to water-soluble N-glycosides of the antibiotics cycloserine and the polymyxins, wherein one or more of the free amino groups of the antibiotic are condensed with the aldose radical of glucose, mannose, arabinose, xylose, ribose or maltose. The polymyxins are tyrothricin, colistin, or bacitracin, which may form any of mono-, di-, tri-, tetra-, or penta-N-glycosides, the particular colistin specified being Colistin A. The glycosides are prepared by warming an aqueous or meth...

Polymyxin B or E or both is or are purified by treating a predominantly aqueous solution of an acid addition salt of polymyxin containing either or both of these polymyxins with an alkali at a pH above 8.5, and preferably 8.5 to 11.0, in the presence of a chelating agent and separat ing the precipitate

Novel water-soluble acylphenylacylamino-1,3-propane-diols of Formula I wherein R is an alkyl, cyclopentyl, cyclohexyl or phenyl group, and R2 is a palmitoyl, palmitoyloxyacetyl or hemi-succinoyl group, are prepared by reacting an acylphenyl-acylamino-1,3-propanediol with succinic anhydride at about 80 DEG C. in the presence of substantially anhydrous pyridine over a period of about three hours, or by reacting the acylphenyl-acylamino - 1,3 - propanediol with palmitoyl or palm...