A combination of: a first tetracycline (TC) component

The present invention relates to an improved method for treating a wide range of inflammatory disorders by administering a tetracycline compound together with an effective inhibitor of tetracycline absorption such as polyvalent metals. Pharmaceutical compositions used in that method are also taught.

FIELD: chemistry.SUBSTANCE: invention relates to a tosylate of a tetracycline compound of formula 1 polymorphous forms thereof a method for production thereof and pharmaceutical compositions based thereon..EFFECT: compounds can be used to treat tetracycline-sensitive conditions.33 cl 10 tbl 10 dwg 10 ex

A method of treating acne in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat acne but has substantially no antibiotic activity without administering a bisphosphonate compound.

Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelerating the return of skin integrity and or in treating or alleviating a disorder including a wound burn impetigo acne rosacea a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of...

7-Disubstituted-phenyl tetracycline compounds are disclosed herein. Also disclosed is a method for treatment or prevention of spinal muscular atrophy using the 7-disubstituted- phenyl tetracycline compounds.

The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible...

A combination of: a first tetracycline (TC) component; and a second component capable of releasing nitric oxide (NO) or a nitrate capable of mimicking NO effects in vivo (NO mimetic). The combinations of the invention advantageously act as more effective MMP modulators with selective reductions in circulating MMP-9 levels in-vivo and inhibitory effects on MMP-2 and MMP-9 levels in-vitro. The combinations of the invention also advantageously act as modulators of inflammation mediators. The co-exi...