The present invention relates to an improved method for treating a wide range of inflammatory disorders by administering a tetracycline compound together with an effective inhibitor of tetracycline absorption such as polyvalent metals. Pharmaceutical compositions 5 used in that method are also taught.

The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. T...

The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible...

The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible...

The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention a substituted tetracyc...

A method for producing a sustained-release tablet having improved stability and content uniformity is provided. The method involves first preparing a core tablet by granulating drying milling blending and compressing a mixture of active and inactive ingredients. Four coating layers are applied to the core tablet: an inner layer an enteric coating layer an active layer and an outer layer. The active ingredient may be a tetracycline such as doxycycline. A sustained-release tablet prepared accordin...