The invention relates to a combination product comprising: a composition A comprising at least one filler product and a composition B comprising at least one compound of the tetracycline family used at a subantimicrobial dose for the treatment of skin aging and scars compositions A and B being used simultaneously separately or sequentially over time. The invention also relates to a single pharmaceutical composition comprising in the same physiologically acceptable medium at least one filler prod...

The present invention relates to compositions for the modulation of inflammation in connective tissues in humans and animals and the modulation of markers of such inflammation including COX-2 TNF-a IL-1 (3 iNOS p38 and chemokines comprising any or all of anabolic anti-catabolic anti-oxidant and analgesic agents including aminosugars S-adenosylmethionine arachadonic acid GAGs including pentosan collagen type II tetracyclines or tetracycline-like compounds diacerin super oxide dismutase L-ergothio...

Methods and compositions for the treatment of skin disorders (e.g. acne rosacea) are described

The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.

A combination therapy for treating a bacterial biofilm comprises a therapeutically effective amount of an antibiotic comprising an aminoglycoside or tetracycline or a combination of two or more thereof and a cationic porphyrin in an amount effective for enhancing the effectiveness of the antibiotic in treating the bacterial biofilm. A method of treating a bacterial biofilm comprising Pseudomonas aeruginosa comprises contacting the bacterial biofilm with a combination therapy comprising a therape...

Methods and compositions for the treatment of skin disorders (

Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelerating the return of skin integrity and or in treating or alleviating a disorder including impetigo, acne, rosacea, a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease, wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin, or...

Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelerating the return of skin integrity and or in treating or alleviating a disorder including impetigo acne rosacea a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin or muco...

The invention relates to a combination product comprising: a composition A comprising at least one filler product and a composition B comprising at least one compound of the tetracycline family used at a subantimicrobial dose for the treatment of skin aging and scars compositions A and B being used simultaneously separately or sequentially over time. The invention also relates to a single pharmaceutical composition comprising in the same physiologically acceptable medium at least one filler prod...