Provided are methods and compositions for clinical treatment of solid tumors (e.g., advanced solid tumors) using anti-ErbB3 antibodies combined with a second agent selected from the group consisting of gemcitabine, carboplatin, pemetrexed, and cabazitaxel. Also provided are methods and compositions for clinical treatment of solid tumors using anti-ErbB3 antibodies combined with cetuximab and irinotecan.

New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I Formula I.1 Formula I.2 Formula IA Formula IB Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine doxorubicin daunorubicin cyclophosphamide busulfex busulfan vinblastine vincristine bleomycin e...

The present invention relates to a combination therapy of propane-1-sulfonic acid {3-[5-(4- chlorophenyl)-1H-pyrrolo [2,3-b] pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide, or a pharmaceutically acceptable salt thereof, and a topoisomerase inhibitor for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. In particular, the present invention relates to such a therapy wherein the topoisomerase inhib...

FIELD: medicine pharmaceutics.SUBSTANCE: there are offered: an anti-cancer combination formed by VEGF Trap inhibitor with irinotecan and therapeutically applicable in treating neoplastic diseases and a product containing it. What is shown is synergic action of the combination in growth inhibition of colonic carcinoma.EFFECT: invention enables using the ingredients of the combination in lower doses vs those applicable separately and increasing activity with reduced toxicity or inhibiting their ma...

The present invention provides for novel crystalline forms of irinotecan hydrochloride and processes for their preparation pharmaceutical compositions containing the novel forms and methods for treating metastatic carcinoma of the colon or rectum using same.