The invention relates to a pharmaceutical composition as tablets for the treatment of hyperlipoproteinemia, hypercholesterolemia and atherosclerosis. According to the invention, the composition comprises amorphous rosuvastatin calcium stabilized with calcium carbonate admixed in a mass ratio of 0.5...2:1 and other excipients, as follows: 30...60% lactose monohydrate, 15...35% micro crystalline cellulose, 1...5% crospovidone, 0.25...5% magnesium stearate.

There is provided a process for the preparation of a compound of formula (7) wherein R1 represents an alkyl group; R2 represents an aryl group; R3 represents hydrogen a protecting group or an alkyl group; and R4 represents hydrogen a protecting group or a SO2R5 group where R5 is an alkyl group which comprises a) hydroxylating a compound of formula (1) wherein Y represents a halo group; P1 represents hydrogen or a protecting group and W represents =O or -OP2 in which P2 represents hydrogen or a p...

The present invention relates to rosuvastatin calcium and a method for preparing an intermediate thereof. Specifically, disclosed are an intermediate compound for preparing rosuvastatin calcium and a preparation method thereof. Structures of the intermediate are shown respectively by a formula II, a formula III, a formula VI or a formula VII in the specification. Further disclosed is a preparation method of rosuvastatin or a salt thereof. The method is based on the five intermediate compounds an...

Disclosed are intermediate as shown in formula V or VI and preparation method thereof, and method for preparing rosuvastatin or salts thereof such as its calcium salt from these intermediates.

This invention relates to the discovery of novel rosuvastatin and atorvastatin analogues.