Addiction to opiate drugs, e.g., heroin, is treated by administering a beta-adrenergic-receptor-blocking drug, e.g. propranolol, which is found to block the rewarding and euphoric effects of the narcotic and to prevent the recurrence of hunger for the narcotic after withdrawal with methadone.

1403841 Antidepressant medicines IMPERIAL CHEMICAL INDUSTRIES Ltd 1 March 1974 [22 March 1973] 13795/73 Heading A5B [Also in Division C2] Therapeutic compositions having antidepressant activity comprise compounds of formula: wherein R1 is a hydrogen atom, an unsubstituted phenyl, naphthyl, furyl, thienyl or pyridyl radical, or a phenyl radical substituted by 1 or 2 substituents selected from halogen atoms, alkyl, haloalkyl, alkoxy and alkylthio radicals of 1 to 4 carbon atoms, dialkylam...

Suitable derivs. of the propionic acid cpd are the esters, amides, and salts prefp. the Na or K salt or the ethyl ester. The propranolol is 1-isopropylamino-3-naphth-1yloxy-prpan-2-ol and the Practolol is 4-(2-hydroxy-3-isopropylaminopropoxy)-acetanilide. The compsns are esp. useful for treatment of angina pectoris.

1277601 Injectable local anaesthetics ESPE FABRIK PHARMAZEUTISCHER PRAPARATE GmbH 24 Oct 1969 [31 Oct 1968] 52143/69 Heading A5B Injectable local anaesthetics contain in aqueous solution a local anaesthetic active agent, a vasoconstrictor and a beta-receptor blocking agent. The solution preferably contains 0.2 to 4% by weight of the local anaesthetic, 10 to 100 ppm of the vasoconstrictor and at least 50 ppm of the beta receptor blocking agent. The local anaesthetic active agent may be #-diethyla...

1,189,782. Propranolol salts. ETABS. NATIVELLE S.a.r.1. 8 Jan., 1968 [16 Jan., 1967], No. 1052/68. Heading C2C. Salts of the general formula (R 1 , 2 = H, alkyl, cycloalkyl, aryl or aralkyl, each group optionally carrying one or more halogen substituents) are prepared from propranolol and the appropriate acid. These compounds possess anti-arrhythmic, hypotensive and sedative properties, and may be administered in the form of pharmaceutical preparations containing them together with a carrier.

1,177,548. Pharmaceutical C.N.S.-depressant compositions. IMPERIAL CHEMICAL INDUSTRIES Ltd. 29 Nov., 1968 [28 Nov., 1967], No. 54124/67. Heading A5B. [Also in Division C2] Pharmaceutical composition, possessing central nervous depressant activity and suitable for oral or parenteral administration, contain as active ingredients at least one of the novel amides of the formula wherein A is O or -NH-