Sustained release dosage forms for twice daily oral dosing to a human patient for providing relief from pain are provided. The sustained release dosage form comprises an immediate release component and a sustained release component, wherein the immediate release component and the sustained release component collectively contain a therapeutically effective amount of an opioid analgesic and a therapeutically effective amount of nonopioid analgesic. In a preferred embodiment, the nonopioid analgesi...

A medicament tablet containing paracetamol (acetaminophen) as the (or an) active ingredient, and an encapsulated flavorant. The tablet may be swallowed in tablet form or may be dissolved or dispersed in water to form a palatable drink.

The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug analogs. This invention relates to a method for the production of a broad group of glycosylated drugs, including but not limited to propofol, acetaminophen, and camptothecin carbohydrate derivatives.

A solid preparation for internal use which is characterized in that ambroxol hydrochloride, L-carbocysteine and acetaminophen are simultaneously formulated and are allowed to coexist. In this solid preparation for internal use which has high product value, the decomposition of the ambroxol hydrochloride by the L-carbocysteine over time is significantly suppressed and the medicinal effects of both components are fully exhibited.

A composition comprising reduced glutathione and acetaminophen and preparation method thereof. The main drug of the composition is 0.1%-99.9% reduced glutathione, 99.9%-1% acetaminophen. The composition can be formulated as tablets, sustained / controlled release formulations, capsules, pills, syrups, films, granules, oral solutions, oral suspensions, oral emulsions, oral powders and any other pharmaceutically acceptable dosage forms. The composition can effectively prevent damage and necrosis o...

A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, or acetaminophen is provided. This 5 method provides improved therapeutic effect, in particular pain relief, over extended time periods.

The present invention relates to an acetaminophen injectable aqueous solution for use in the treatment or in the prevention of pain by spinal administration, wherein said acetaminophen injectable solution is supersaturated. In certain embodiments, the acetaminophen injectable aqueous solution is administered simultaneously, separately or sequentially with a local anaesthetic by spinal administration.

The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and...